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Real-time microstructural and functi...

Westphal, Volker.

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Real-time microstructural and functional imaging and image processing in optical coherence tomography.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Real-time microstructural and functional imaging and image processing in optical coherence tomography./
作者:	Westphal, Volker.
面頁冊數:	237 p.
附註:	Source: Dissertation Abstracts International, Volume: 63-05, Section: B, page: 2447.
Contained By:	Dissertation Abstracts International63-05B.
標題:	Physics, Optics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3052295
ISBN:	0493666818

Real-time microstructural and functional imaging and image processing in optical coherence tomography.
Westphal, Volker.

Real-time microstructural and functional imaging and image processing in optical coherence tomography. - 237 p.

Source: Dissertation Abstracts International, Volume: 63-05, Section: B, page: 2447.

Thesis (Ph.D.)--Case Western Reserve University, 2002.

Optical Coherence Tomography (OCT) is a noninvasive optical imaging technique that allows high-resolution cross-sectional imaging of tissue microstructure, achieving a spatial resolution of about 10 mum. OCT is similar to B-mode ultrasound (US) except that it uses infrared light instead of ultrasound. In contrast to US, no coupling gel is needed, simplifying the image acquisition. Furthermore, the fiber optic implementation of OCT is compatible with endoscopes. In recent years, the transition from slow imaging, bench-top systems to real-time clinical systems has been under way. This has lead to a variety of applications, namely in ophthalmology, gastroenterology, dermatology and cardiology.

ISBN: 0493666818Subjects--Topical Terms:

1018756
Physics, Optics.

Real-time microstructural and functional imaging and image processing in optical coherence tomography.
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500 $a Adviser: Joseph A. Izatt.
502 $a Thesis (Ph.D.)--Case Western Reserve University, 2002.
520 $a Optical Coherence Tomography (OCT) is a noninvasive optical imaging technique that allows high-resolution cross-sectional imaging of tissue microstructure, achieving a spatial resolution of about 10 mum. OCT is similar to B-mode ultrasound (US) except that it uses infrared light instead of ultrasound. In contrast to US, no coupling gel is needed, simplifying the image acquisition. Furthermore, the fiber optic implementation of OCT is compatible with endoscopes. In recent years, the transition from slow imaging, bench-top systems to real-time clinical systems has been under way. This has lead to a variety of applications, namely in ophthalmology, gastroenterology, dermatology and cardiology.
520 $a First, this dissertation will demonstrate that OCT is capable of imaging and differentiating clinically relevant tissue structures in the gastrointestinal tract. A careful in vitro correlation study between endoscopic OCT images and corresponding histological slides was performed.
520 $a Besides structural imaging, OCT systems were further developed for functional imaging, as for example to visualize blood flow. Previously, imaging flow in small vessels in real-time was not possible. For this research, a new processing scheme similar to real-time Doppler in US was introduced. It was implemented in dedicated hardware to allow real-time acquisition and overlayed display of blood flow in vivo. A sensitivity of 0.5mm/s was achieved.
520 $a Optical coherence microscopy (OCM) is a variation of OCT, improving the resolution even further to a few micrometers. Advances made in the OCT scan engine for the Doppler setup enabled real-time imaging in vivo with OCM.
520 $a In order to generate geometrical correct images for all the previous applications in real-time, extensive image processing algorithms were developed. Algorithms for correction of distortions due to non-telecentric scanning, nonlinear scan mirror movements, and refraction were developed and demonstrated. This has led to interesting new applications, as for example in imaging of the anterior segment of the eye.
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