東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Human whole-body gas exchange and ce...

Lu, Kun.

Linked to FindBook

Google Book

Amazon

博客來

Human whole-body gas exchange and cerebral autoregulation studied using a cardiopulmonary model.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Human whole-body gas exchange and cerebral autoregulation studied using a cardiopulmonary model./
Author:	Lu, Kun.
Description:	130 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0871.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3122506

Human whole-body gas exchange and cerebral autoregulation studied using a cardiopulmonary model.
Lu, Kun.

Human whole-body gas exchange and cerebral autoregulation studied using a cardiopulmonary model. - 130 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0871.

Thesis (Ph.D.)--Rice University, 2004.

The goal of this work is to study human whole-body gas exchange and cerebral autoregulation using a mathematical model. Previously, a human cardiopulmonary (CP) model [45, 47] was developed, which included heart, closed-loop blood circulation, gas exchange at lungs and baroreflex control of arterial pressure. In the current study, two major extensions to the model are made. First, a description of gas exchange in the peripheral tissues is added and is coupled with the lung gas exchanger via the circulatory loop with variable transport delays. A peripheral chemosensitive loop is also added to mimic the influence of blood gas composition on the heart and vasculature. The CP model is then used to predict the integrated cardiovascular and blood-tissue gas transport responses to pronounced changes in lung gas composition, and thus simulates changes encountered in apnea with and without passive oxygenation. The second extension of the CP model includes a more detailed description of cerebral circulation, cerebrospinal fluid (CSF) dynamics, brain gas exchange and cerebral blood flow (CBF) autoregulation. Two CBF regulatory mechanisms are described: autoregulation and CO2 reactivity. Central chemoreceptor control of ventilation is also added. This new model is subsequently used to study cerebral hemodynamic and brain gas exchange responses to test protocols commonly used in the assessment of CBF autoregulation (e.g., carotid artery compression and the thigh cuff test). The model closely mimics the experimental findings and provides biophysically based insights into the dynamics and interactions of the associated physiological systems. In summary, this work represents a bold effort in large-scale modeling of physiological systems. The presented model accurately describes the physiological systems and can explain how the cardiovascular, pulmonary and autonomic nervous systems interact in response to a variety of cardiopulmonary challenges, such as apnea, carotid artery compression and the thigh cuff test. With further refinement, the model may help investigators to better understand the complex biophysics of cardiopulmonary diseases such as sleep-related disorders of breathing (obstructive and central sleep apnea) and complications associated with head-injuries.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Human whole-body gas exchange and cerebral autoregulation studied using a cardiopulmonary model.
LDR:03298nmm 2200313 4500 001 1862293
005 20041215100248.5
008 130614s2004 eng d
035 $a (UnM)AAI3122506
035 $a AAI3122506
040 $a UnM $c UnM
100 1 $a Lu, Kun. $3 1677393
245 1 0 $a Human whole-body gas exchange and cerebral autoregulation studied using a cardiopulmonary model.
300 $a 130 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0871.
500 $a Co-Chairmen: Fathi H. Ghorbel; John W. Clark, Jr.
502 $a Thesis (Ph.D.)--Rice University, 2004.
520 $a The goal of this work is to study human whole-body gas exchange and cerebral autoregulation using a mathematical model. Previously, a human cardiopulmonary (CP) model [45, 47] was developed, which included heart, closed-loop blood circulation, gas exchange at lungs and baroreflex control of arterial pressure. In the current study, two major extensions to the model are made. First, a description of gas exchange in the peripheral tissues is added and is coupled with the lung gas exchanger via the circulatory loop with variable transport delays. A peripheral chemosensitive loop is also added to mimic the influence of blood gas composition on the heart and vasculature. The CP model is then used to predict the integrated cardiovascular and blood-tissue gas transport responses to pronounced changes in lung gas composition, and thus simulates changes encountered in apnea with and without passive oxygenation. The second extension of the CP model includes a more detailed description of cerebral circulation, cerebrospinal fluid (CSF) dynamics, brain gas exchange and cerebral blood flow (CBF) autoregulation. Two CBF regulatory mechanisms are described: autoregulation and CO2 reactivity. Central chemoreceptor control of ventilation is also added. This new model is subsequently used to study cerebral hemodynamic and brain gas exchange responses to test protocols commonly used in the assessment of CBF autoregulation (e.g., carotid artery compression and the thigh cuff test). The model closely mimics the experimental findings and provides biophysically based insights into the dynamics and interactions of the associated physiological systems. In summary, this work represents a bold effort in large-scale modeling of physiological systems. The presented model accurately describes the physiological systems and can explain how the cardiovascular, pulmonary and autonomic nervous systems interact in response to a variety of cardiopulmonary challenges, such as apnea, carotid artery compression and the thigh cuff test. With further refinement, the model may help investigators to better understand the complex biophysics of cardiopulmonary diseases such as sleep-related disorders of breathing (obstructive and central sleep apnea) and complications associated with head-injuries.
590 $a School code: 0187.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Biophysics, General. $3 1019105
690 $a 0541
690 $a 0548
690 $a 0433
690 $a 0760
690 $a 0786
710 2 0 $a Rice University. $3 960124
773 0 $t Dissertation Abstracts International $g 65-02B.
790 1 0 $a Ghorbel, Fathi H., $e advisor
790 1 0 $a Clark, John W., Jr., $e advisor
790 $a 0187
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3122506