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Mechanism of pharmaceutically releva...

Barron, Lorena B.

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Mechanism of pharmaceutically relevant oxidation processes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanism of pharmaceutically relevant oxidation processes./
Author:	Barron, Lorena B.
Description:	210 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0750.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Chemistry, Pharmaceutical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3122184

Mechanism of pharmaceutically relevant oxidation processes.
Barron, Lorena B.

Mechanism of pharmaceutically relevant oxidation processes. - 210 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0750.

Thesis (Ph.D.)--University of Kansas, 2003.

In recent years, the advances in biotechnology have yielded an increased number of recombinant protein pharmaceutical products. The inherent instability of these biomolecules has led to many difficulties with degradation in the drug development process. One of the primary pathways of degradation is through oxidative processes in solution and solid state. In solution, the primary mechanism of oxidation is via chain reactions initiated by hydrogen or electron transfer resulting from exposure to light, heat, and catalytic levels of redox-active transition metals. Yet, very little information can be found on oxidation processes in the solid state. Hence, in order to gain a better understanding of oxidative processes in the solid state, our work considers the design of a photochemical initiator for use in the solid state, as well as its application to a solid state reaction, in which the reaction mechanism involves the transfer of hydrogen. We will also present model systems of direct oxidation by transition metals in the solid state, using catechol and dopamine, two catecholic compounds that have been studied extensively in solution. Finally we will present two examples of how a protein's direct interaction with transition metals can be affected by the protein's structure and chemical properties resulting in changes in conformation, bioactivity, and toxicity.Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Mechanism of pharmaceutically relevant oxidation processes.
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035 $a (UnM)AAI3122184
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100 1 $a Barron, Lorena B. $3 1949187
245 1 0 $a Mechanism of pharmaceutically relevant oxidation processes.
300 $a 210 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0750.
500 $a Chair: Christian Schoneich.
502 $a Thesis (Ph.D.)--University of Kansas, 2003.
520 $a In recent years, the advances in biotechnology have yielded an increased number of recombinant protein pharmaceutical products. The inherent instability of these biomolecules has led to many difficulties with degradation in the drug development process. One of the primary pathways of degradation is through oxidative processes in solution and solid state. In solution, the primary mechanism of oxidation is via chain reactions initiated by hydrogen or electron transfer resulting from exposure to light, heat, and catalytic levels of redox-active transition metals. Yet, very little information can be found on oxidation processes in the solid state. Hence, in order to gain a better understanding of oxidative processes in the solid state, our work considers the design of a photochemical initiator for use in the solid state, as well as its application to a solid state reaction, in which the reaction mechanism involves the transfer of hydrogen. We will also present model systems of direct oxidation by transition metals in the solid state, using catechol and dopamine, two catecholic compounds that have been studied extensively in solution. Finally we will present two examples of how a protein's direct interaction with transition metals can be affected by the protein's structure and chemical properties resulting in changes in conformation, bioactivity, and toxicity.
590 $a School code: 0099.
650 4 $a Chemistry, Pharmaceutical. $3 550957
690 $a 0491
710 2 0 $a University of Kansas. $3 626626
773 0 $t Dissertation Abstracts International $g 65-02B.
790 1 0 $a Schoneich, Christian, $e advisor
790 $a 0099
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3122184