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Synthetic studies on anti-cancer and...

Headrick, Sarah Autumn.

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Synthetic studies on anti-cancer and anti-HIV compounds.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthetic studies on anti-cancer and anti-HIV compounds./
Author:	Headrick, Sarah Autumn.
Description:	325 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-09, Section: B, page: 4355.
Contained By:	Dissertation Abstracts International64-09B.
Subject:	Chemistry, Organic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3104387

Synthetic studies on anti-cancer and anti-HIV compounds.
Headrick, Sarah Autumn.

Synthetic studies on anti-cancer and anti-HIV compounds. - 325 p.

Source: Dissertation Abstracts International, Volume: 64-09, Section: B, page: 4355.

Thesis (Ph.D.)--The University of Tennessee, 2003.

The research discussed in this dissertation focuses on the synthesis and biological evaluation of two families of therapeutic agents.Subjects--Topical Terms:

516206
Chemistry, Organic.

Synthetic studies on anti-cancer and anti-HIV compounds.
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100 1 $a Headrick, Sarah Autumn. $3 1948987
245 1 0 $a Synthetic studies on anti-cancer and anti-HIV compounds.
300 $a 325 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-09, Section: B, page: 4355.
500 $a Adviser: David C. Baker.
502 $a Thesis (Ph.D.)--The University of Tennessee, 2003.
520 $a The research discussed in this dissertation focuses on the synthesis and biological evaluation of two families of therapeutic agents.
520 $a In 1999 a group of scientists at the National Cancer Institute reported that during a screening of their database they had found an active non-nucleoside reverse transcriptase inhibitor. This compound (NSC-108406) was substantially more potent than the other inhibitors identified during their screening with an IC50 of 0.5 +/- 0.3 muM. During a cell-based antiviral screen, it was found to provide an EC50 of 1.5 +/- 1.0 muM. In an effort to increase the potency of the lead, a set of analogs of NSC-108406 was synthesized in our laboratories, providing a compound with an EC 50 of 0.036 muM.
520 $a Hydramycin is a naturally occurring pluramycinone that is a potent antimicrobial and antitumor agent and whose biological activity has created an interest in its synthesis. Our work began with a model study that established a strategy by which the pyranone system and associated functionality could be realized. The route makes use of a novel alkyne and a fluoride-induced ring closure that provided a molecule consisting of a chromenone with the essential moieties analogous to those of hydramycin. The protocol was applied to a compound containing the hydramycin anthraquinone system via a 2-formyl-1-hydroxy anthraquinone that was coupled with an alkyne.
590 $a School code: 0226.
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Chemistry, Pharmaceutical. $3 550957
690 $a 0490
690 $a 0491
710 2 0 $a The University of Tennessee. $3 1022026
773 0 $t Dissertation Abstracts International $g 64-09B.
790 1 0 $a Baker, David C., $e advisor
790 $a 0226
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3104387