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Cellular and molecular mechanisms in...

Mitchell, Patrick Oliver James.

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Cellular and molecular mechanisms involved in skeletal muscle adaptation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Cellular and molecular mechanisms involved in skeletal muscle adaptation./
作者:	Mitchell, Patrick Oliver James.
面頁冊數:	194 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0505.
Contained By:	Dissertation Abstracts International64-02B.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3080344

Cellular and molecular mechanisms involved in skeletal muscle adaptation.
Mitchell, Patrick Oliver James.

Cellular and molecular mechanisms involved in skeletal muscle adaptation. - 194 p.

Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0505.

Thesis (Ph.D.)--Emory University, 2003.

Maintaining sufficient lean body mass in the form of skeletal muscle is essential for sustaining good health and quality of life in an individual. A wide variety of different conditions directly or indirectly result in the loss of skeletal muscle. The cellular and molecular pathways that are responsible for regulating maintenance and growth of adult skeletal muscle are not well understood. The work presented in this dissertation describes specific cellular and molecular pathways that are involved during atrophy and growth of phenotypically disparate hindlimb muscles. Based on the following observations, we propose that atrophy and growth of specific muscle types is a complex process involving multiple cellular and molecular mechanisms. (1) Atrophy of the soleus muscle, but not the plantaris, results in myonuclear loss thereby leading to the requirement for additional myonuclei during its subsequent growth. (2) Muscle precursor cells from atrophied muscles are fewer in number and exhibit decreased capacity to form differentiated myogenic cells. (3) Growth of the soleus muscle occurs in distinct stages in contrast to the plantaris. Early growth is mediated by myofiber-intrinsic processes and later growth is dependent on muscle precursor cells. (4) Activity of the phosphatase calcineurin is required for maintenance and growth of the plantaris, however only later growth of the soleus is dependent on calcineurin activity. In summary, we conclude that skeletal muscle atrophy and growth proceeds via multiple regulatory mechanisms that depend on muscle function and the type of growth stimulus applied to the muscle.Subjects--Topical Terms:

1017686
Biology, Cell.

Cellular and molecular mechanisms involved in skeletal muscle adaptation.
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500 $a Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0505.
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502 $a Thesis (Ph.D.)--Emory University, 2003.
520 $a Maintaining sufficient lean body mass in the form of skeletal muscle is essential for sustaining good health and quality of life in an individual. A wide variety of different conditions directly or indirectly result in the loss of skeletal muscle. The cellular and molecular pathways that are responsible for regulating maintenance and growth of adult skeletal muscle are not well understood. The work presented in this dissertation describes specific cellular and molecular pathways that are involved during atrophy and growth of phenotypically disparate hindlimb muscles. Based on the following observations, we propose that atrophy and growth of specific muscle types is a complex process involving multiple cellular and molecular mechanisms. (1) Atrophy of the soleus muscle, but not the plantaris, results in myonuclear loss thereby leading to the requirement for additional myonuclei during its subsequent growth. (2) Muscle precursor cells from atrophied muscles are fewer in number and exhibit decreased capacity to form differentiated myogenic cells. (3) Growth of the soleus muscle occurs in distinct stages in contrast to the plantaris. Early growth is mediated by myofiber-intrinsic processes and later growth is dependent on muscle precursor cells. (4) Activity of the phosphatase calcineurin is required for maintenance and growth of the plantaris, however only later growth of the soleus is dependent on calcineurin activity. In summary, we conclude that skeletal muscle atrophy and growth proceeds via multiple regulatory mechanisms that depend on muscle function and the type of growth stimulus applied to the muscle.
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