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Bone formation during limb lengtheni...

Guichet, Jean-Marc.

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Bone formation during limb lengthening: Animal experimentation with and without preservation of the bone marrow and/or periosteum.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Bone formation during limb lengthening: Animal experimentation with and without preservation of the bone marrow and/or periosteum./
Author:	Guichet, Jean-Marc.
Description:	218 p.
Notes:	Source: Dissertation Abstracts International, Volume: 60-09, Section: B, page: 4511.
Contained By:	Dissertation Abstracts International60-09B.
Subject:	Health Sciences, Medicine and Surgery. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9945283
ISBN:	0599472634

Bone formation during limb lengthening: Animal experimentation with and without preservation of the bone marrow and/or periosteum.
Guichet, Jean-Marc.

Bone formation during limb lengthening: Animal experimentation with and without preservation of the bone marrow and/or periosteum. - 218 p.

Source: Dissertation Abstracts International, Volume: 60-09, Section: B, page: 4511.

Thesis (Ph.D.)--New York University, 1999.

Although surgical treatment for lower limb length discrepancy is well established, the pathophysiology of bone formation during gradual length correction is not clearly understood. To date, no animal studies have quantitatively delineated the spatial and temporal evolution of bone during healing of a lengthening defect, nor the relative role of bone marrow vs. periosteum in lengthening regenerate formation. Quantifying their respective roles is of primary importance for orthopaedic pathologies such as limb length discrepancies and pseudarthrosis.

ISBN: 0599472634Subjects--Topical Terms:

1017756
Health Sciences, Medicine and Surgery.

Bone formation during limb lengthening: Animal experimentation with and without preservation of the bone marrow and/or periosteum.
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020 $a 0599472634
035 $a (UnM)AAI9945283
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040 $a UnM $c UnM
100 1 $a Guichet, Jean-Marc. $3 1948329
245 1 0 $a Bone formation during limb lengthening: Animal experimentation with and without preservation of the bone marrow and/or periosteum.
300 $a 218 p.
500 $a Source: Dissertation Abstracts International, Volume: 60-09, Section: B, page: 4511.
500 $a Adviser: Margareta Nordin.
502 $a Thesis (Ph.D.)--New York University, 1999.
520 $a Although surgical treatment for lower limb length discrepancy is well established, the pathophysiology of bone formation during gradual length correction is not clearly understood. To date, no animal studies have quantitatively delineated the spatial and temporal evolution of bone during healing of a lengthening defect, nor the relative role of bone marrow vs. periosteum in lengthening regenerate formation. Quantifying their respective roles is of primary importance for orthopaedic pathologies such as limb length discrepancies and pseudarthrosis.
520 $a This dissertation describes bone regenerate formation during limb lengthening in the early phase of healing. It includes a study of the calcified bone regenerate itself, and of cartilage and fibrous tissue formation. Using surgical techniques that modified the amount of bone, cartilage, and soft tissue deposition, the relative participation of the bone marrow and periosteum in lengthening regenerate formation in the rabbit at day 30 postsurgery was addressed. Evaluations were performed with dual energy x-ray absorptiometry (preliminary study) and histomorphometry (main study), augmented by a statistical study.
520 $a Bone formation from the periosteum was found to spread in the distraction gap and along the diaphysis. Preservation of both periosteum and bone marrow resulted in a higher density of bone formed at the cortical site. Although bone thickness and density at these sites are related to respective tissues, an interaction effect was also found. When both periosteum and bone marrow are destroyed, fibrous tissue (but not bone) fills the distraction gap. Progenitor cells appear linked to periosteum and bone marrow tissues, but not to muscle.
520 $a If the periosteum provides a higher quantity of calcified bone, preserving it along with the bone marrow may represent the ideal combination to restore the biomechanical properties of bone. From this arises a new concept, "osteostasis": the bone, when injured (e.g., fracture or lengthening) acts to restore its mechanical function, within the body and with respect to the environment, by all means possible (e.g., periosteum, bone marrow, hormones), based on mechanical stimulus.
520 $a The practical lesson is that surgical preservation of both periosteum and bone marrow is most effective for bone healing. Clinical efforts should focus on less invasive surgery.
590 $a School code: 0146.
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Rehabilitation and Therapy. $3 1017926
690 $a 0564
690 $a 0433
690 $a 0382
710 2 0 $a New York University. $3 515735
773 0 $t Dissertation Abstracts International $g 60-09B.
790 1 0 $a Nordin, Margareta, $e advisor
790 $a 0146
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9945283