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Isoflavones and their novel analogue...

Lynch, Launa M. J.

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Isoflavones and their novel analogues: Effects on EGFR and PTEN/AKT-mediated signaling pathways in glioblastoma multiforme cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Isoflavones and their novel analogues: Effects on EGFR and PTEN/AKT-mediated signaling pathways in glioblastoma multiforme cells./
Author:	Lynch, Launa M. J.
Description:	159 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1199.
Contained By:	Dissertation Abstracts International64-03B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3083903

Isoflavones and their novel analogues: Effects on EGFR and PTEN/AKT-mediated signaling pathways in glioblastoma multiforme cells.
Lynch, Launa M. J.

Isoflavones and their novel analogues: Effects on EGFR and PTEN/AKT-mediated signaling pathways in glioblastoma multiforme cells. - 159 p.

Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1199.

Thesis (Ph.D.)--Idaho State University, 2003.

The effects of isoflavones on signaling cascades downstream from the epidermal growth factor receptor that are important to the progression of glioblastoma multiforme were investigated. Biochanin A, daidzein, and genistein were the isoflavones chosen for these studies. Human (U87MG) and Rat (C6) cells were treated with the isoflavones and their effects on the levels of PLCgamma-1, JNK-1, p38 and Erk-1 proteins were determined.Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Isoflavones and their novel analogues: Effects on EGFR and PTEN/AKT-mediated signaling pathways in glioblastoma multiforme cells.
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008 130614s2003 eng d
035 $a (UnM)AAI3083903
035 $a AAI3083903
040 $a UnM $c UnM
100 1 $a Lynch, Launa M. J. $3 1948126
245 1 0 $a Isoflavones and their novel analogues: Effects on EGFR and PTEN/AKT-mediated signaling pathways in glioblastoma multiforme cells.
300 $a 159 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1199.
500 $a Adviser: Alok Bhushan.
502 $a Thesis (Ph.D.)--Idaho State University, 2003.
520 $a The effects of isoflavones on signaling cascades downstream from the epidermal growth factor receptor that are important to the progression of glioblastoma multiforme were investigated. Biochanin A, daidzein, and genistein were the isoflavones chosen for these studies. Human (U87MG) and Rat (C6) cells were treated with the isoflavones and their effects on the levels of PLCgamma-1, JNK-1, p38 and Erk-1 proteins were determined.
520 $a Biochanin A at 5 muM and 2 muM of daidzein decreased the levels of PLCgamma-1in U87MG cells. At the 2 muM concentration biochanin A and genistein decreased the levels of JNK-1 in U87MG cells. The same concentration of genistein also decreased the levels of this protein in C6 cells. The p38 protein was decreased when the C6 cells were treated with 5 muM of biochanin A. In both cell lines there was a decrease in the levels of Erk-1.
520 $a The PTEN/AKT pathway was investigated because decreases of Erk-1 levels correlate with increases in the PTEN protein. The protein levels of PTEN, PI3K, AKT, and phosphorlyated-AKT were determined. All three isoflavones caused an increase in the levels of the PTEN protein in both cell lines. In the U87MG and C6 cells the increases in PTEN did not affect the levels of PI3K or AKT. Biochanin A inhibited the phosphorylation of AKT at both the threonine-308 site and the serine-473 site in both cell lines.
520 $a The ability of isoflavones to reach the glioblastoma tumor is limited by the blood-brain barrier. Ester and ether prodrugs of the isoflavones were synthesized to increase their delivery. The analogues were more potent in increasing the level of the PTEN protein in U87MG and C6.
520 $a These studies indicate the ability of isoflavones to downregulate the downstream signaling cascades that result in proliferation of glioblastoma multiforme tumors. Analogues that may increase the concentrations of isoflavones in the central nervous system were synthesized and their possible usefulness as agents to treat for this disease was shown through their ability to express the tumor suppressor protein PTEN at low concentrations.
590 $a School code: 0320.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0419
690 $a 0491
690 $a 0992
710 2 0 $a Idaho State University. $3 1023169
773 0 $t Dissertation Abstracts International $g 64-03B.
790 1 0 $a Bhushan, Alok, $e advisor
790 $a 0320
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3083903