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A comparison of three methods used t...

Spratt, Heidi Marie.

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A comparison of three methods used to determine functionally important protein residues.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A comparison of three methods used to determine functionally important protein residues./
Author:	Spratt, Heidi Marie.
Description:	154 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2258.
Contained By:	Dissertation Abstracts International64-05B.
Subject:	Statistics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090182

A comparison of three methods used to determine functionally important protein residues.
Spratt, Heidi Marie.

A comparison of three methods used to determine functionally important protein residues. - 154 p.

Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2258.

Thesis (Ph.D.)--Rice University, 2003.

A new method for determining functionally important protein residues is analyzed and compared with two previously existing methods. This thesis presents the analysis of several different protein sequences and shows how the functionally important protein residues compare between the evolutionary trace method, the maximum likelihood method of protein evolution, and the Hidden Markov method of protein evolution. The results are presented graphically as well as structurally since structure information is known about all the protein sequences studied. All three methods produce similar results for most of the proteins and show that the most highly conserved protein residues are detectable by all three methods but that the less conserved important residues may not always be identified by all methods.Subjects--Topical Terms:

517247
Statistics.

A comparison of three methods used to determine functionally important protein residues.
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035 $a (UnM)AAI3090182
035 $a AAI3090182
040 $a UnM $c UnM
100 1 $a Spratt, Heidi Marie. $3 1946045
245 1 0 $a A comparison of three methods used to determine functionally important protein residues.
300 $a 154 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2258.
500 $a Chair: Marek Kimmel.
502 $a Thesis (Ph.D.)--Rice University, 2003.
520 $a A new method for determining functionally important protein residues is analyzed and compared with two previously existing methods. This thesis presents the analysis of several different protein sequences and shows how the functionally important protein residues compare between the evolutionary trace method, the maximum likelihood method of protein evolution, and the Hidden Markov method of protein evolution. The results are presented graphically as well as structurally since structure information is known about all the protein sequences studied. All three methods produce similar results for most of the proteins and show that the most highly conserved protein residues are detectable by all three methods but that the less conserved important residues may not always be identified by all methods.
590 $a School code: 0187.
650 4 $a Statistics. $3 517247
650 4 $a Biology, Biostatistics. $3 1018416
650 4 $a Biology, Molecular. $3 1017719
690 $a 0463
690 $a 0308
690 $a 0307
710 2 0 $a Rice University. $3 960124
773 0 $t Dissertation Abstracts International $g 64-05B.
790 1 0 $a Kimmel, Marek, $e advisor
790 $a 0187
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090182