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The effects of physical activity on ...

Vanhelder, Tomas.

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The effects of physical activity on insulin binding to monocytes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The effects of physical activity on insulin binding to monocytes./
作者:	Vanhelder, Tomas.
面頁冊數:	230 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1577.
Contained By:	Dissertation Abstracts International64-04B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ78357
ISBN:	061278357X

The effects of physical activity on insulin binding to monocytes.
Vanhelder, Tomas.

The effects of physical activity on insulin binding to monocytes. - 230 p.

Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1577.

Thesis (Ph.D.)--University of Toronto (Canada), 2003.

Insulin binding to the plasma membrane insulin receptors is the first step in insulin control of a cell's metabolism. Many factors influence insulin binding to plasma membrane receptors. In healthy subjects, the level of physical activity and the level of physical fitness seem to be major contributors. To further clarify the role of exercise in insulin binding, we have investigated the effects of continuous and intermittent types of exercise in untrained and trained subjects on insulin binding, glucose uptake, and changes in circulating leucocyte fractions.

ISBN: 061278357XSubjects--Topical Terms:

1017835
Biology, Animal Physiology.

The effects of physical activity on insulin binding to monocytes.
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245 1 0 $a The effects of physical activity on insulin binding to monocytes.
300 $a 230 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1577.
500 $a Adviser: M. A. Adomski.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2003.
520 $a Insulin binding to the plasma membrane insulin receptors is the first step in insulin control of a cell's metabolism. Many factors influence insulin binding to plasma membrane receptors. In healthy subjects, the level of physical activity and the level of physical fitness seem to be major contributors. To further clarify the role of exercise in insulin binding, we have investigated the effects of continuous and intermittent types of exercise in untrained and trained subjects on insulin binding, glucose uptake, and changes in circulating leucocyte fractions.
520 $a We found that circulating monocytes form the predominant fraction of mononuclear cells that express surface insulin receptors in healthy subjects, whereas circulating T-lymphocytes displayed negligible binding (2%) of insulin receptor-specific antibodies. This confirmed our thesis that monocytes could serve as a model of insulin binding.
520 $a Our results showed that insulin binding decreased after 20 and 60 min of continuous, sub-maximal exercise in aerobically fit male subjects. Similar declines were also observed after 20 min of intermittent exercise. This diminished insulin binding appeared to be due to a decrease in the affinity of insulin receptors rather than to a decline in the total number of insulin receptors.
520 $a Insulin binding in untrained subjects was not altered initially by either continuous or intermittent types of exercise. Following ten weeks of aerobic training of the same subjects, insulin binding was decreased following both types of exercise. Glucose uptake by both basal non-stimulated and insulin-stimulated monocytes was unchanged in both the trained or untrained subjects.
520 $a Our findings show that trained individuals exhibit lower insulin binding and no change in glucose uptake during physical activity, suggestive of a higher efficacy of insulin action in physically fit subjects. We also found that monocytes are the predominant circulating mononuclear cell fraction that binds insulin.
590 $a School code: 0779.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Health Sciences, Recreation. $3 1018003
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792 $a 2003
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