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PyV-mT induced neoplastic progressio...

Maglione, Jeanne Elena.

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PyV-mT induced neoplastic progression in the mouse mammary gland: Insights revealed by the creation and investigation of PyV-mT mammary intraepithelial outgrowth (MIN-O) lines.

Record Type:	Electronic resources : Monograph/item
Title/Author:	PyV-mT induced neoplastic progression in the mouse mammary gland: Insights revealed by the creation and investigation of PyV-mT mammary intraepithelial outgrowth (MIN-O) lines./
Author:	Maglione, Jeanne Elena.
Description:	256 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-11, Section: B, page: 5460.
Contained By:	Dissertation Abstracts International64-11B.
Subject:	Health Sciences, Oncology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3112861

PyV-mT induced neoplastic progression in the mouse mammary gland: Insights revealed by the creation and investigation of PyV-mT mammary intraepithelial outgrowth (MIN-O) lines.
Maglione, Jeanne Elena.

PyV-mT induced neoplastic progression in the mouse mammary gland: Insights revealed by the creation and investigation of PyV-mT mammary intraepithelial outgrowth (MIN-O) lines. - 256 p.

Source: Dissertation Abstracts International, Volume: 64-11, Section: B, page: 5460.

Thesis (Ph.D.)--University of California, San Diego, 2003.

Characterizing preinvasive breast cancer precursors and understanding their complex patholobiology have emerged as important areas of research that may permit more appropriate and effective therapeutic interventions. The potential of genetically engineered mice to reveal information regarding early stages of neoplastic progression has generally been neglected. The goals of this research were: (1) to study the pathobiology of early stages of tumorigenesis in the widely used <italic>Polyomavirus middle T</italic> (<italic>PyV-mT </italic>) transgenic mouse model; (2) to create a premalignant model system to investigate early events in neoplastic progression.Subjects--Topical Terms:

1018566
Health Sciences, Oncology.

PyV-mT induced neoplastic progression in the mouse mammary gland: Insights revealed by the creation and investigation of PyV-mT mammary intraepithelial outgrowth (MIN-O) lines.
LDR:03637nmm 2200301 4500 001 1857100
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035 $a (UnM)AAI3112861
035 $a AAI3112861
040 $a UnM $c UnM
100 1 $a Maglione, Jeanne Elena. $3 1944836
245 1 0 $a PyV-mT induced neoplastic progression in the mouse mammary gland: Insights revealed by the creation and investigation of PyV-mT mammary intraepithelial outgrowth (MIN-O) lines.
300 $a 256 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-11, Section: B, page: 5460.
500 $a Chair: Carol L. MacLeod.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2003.
520 $a Characterizing preinvasive breast cancer precursors and understanding their complex patholobiology have emerged as important areas of research that may permit more appropriate and effective therapeutic interventions. The potential of genetically engineered mice to reveal information regarding early stages of neoplastic progression has generally been neglected. The goals of this research were: (1) to study the pathobiology of early stages of tumorigenesis in the widely used <italic>Polyomavirus middle T</italic> (<italic>PyV-mT </italic>) transgenic mouse model; (2) to create a premalignant model system to investigate early events in neoplastic progression.
520 $a This work provides the first comprehensive histopathological characterization of transgenic PyV-mT hyperplasias. It is the first study to include transplantation experiments to test the growth potential and tumorigenicity of early PyV-mT lesions. PyV-mT induced hyperplastic lesions satisfy the criteria for mammary intraepithelial neoplasia (MIN), and these data prove that neoplastic progression is a multi-step process in this model. The data support the use of <italic> PyV-mT</italic> transgenic mice to investigate the full range of events involved with multi-step neoplastic progression.
520 $a Six stable mammary intraepithelial outgrowth (MIN-O) lines were established to study PyV-mT induced neoplastic progression in detail. Although expression of the <italic>PyV-mT</italic> transgene was the primary initiating event for all lines, they exhibited different tumor latencies, metastatic potentials, and morphologies. These data indicate that diverse pathways of secondary molecular events lead to different outcomes in this model. The MIN-O lines share a number of characteristics with human breast cancer including the observation that gene expression profiles of tumors were more similar to those of the premalignant outgrowth from which they developed than they were to other tumors. This work reinforces the concept that progression in mouse models and humans share similar attributes.
520 $a Three potential uses for the MIN-O lines were explored: (1) pre-clinical trials, (2) identification of candidate genes involved in neoplastic progression and, (3) assessing the importance of specific genes in the non-epithelial three-dimensional microenvironment on tumor progression. These experiments support the usefulness of the MIN-O lines to eludicate the factors driving neoplastic progression both within and ectopic to the mammary epithelium and as a pre-clinical screening tool to identify possible chemoprevention agents.
590 $a School code: 0033.
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Biology, Molecular. $3 1017719
690 $a 0992
690 $a 0307
710 2 0 $a University of California, San Diego. $3 1018093
773 0 $t Dissertation Abstracts International $g 64-11B.
790 1 0 $a MacLeod, Carol L., $e advisor
790 $a 0033
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3112861