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The molecular control of cell moveme...

Ewald, Andrew Josef.

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The molecular control of cell movements during early vertebrate development.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The molecular control of cell movements during early vertebrate development./
Author:	Ewald, Andrew Josef.
Description:	289 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2477.
Contained By:	Dissertation Abstracts International64-06B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3093480

The molecular control of cell movements during early vertebrate development.
Ewald, Andrew Josef.

The molecular control of cell movements during early vertebrate development. - 289 p.

Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2477.

Thesis (Ph.D.)--California Institute of Technology, 2003.

The early development of vertebrate embryos is characterized by massive, coordinated cell movements. These movements shape the embryo, distribute different cell types, shape complex tissues, and bring tissues into their correct spatial relationships. We have examined two early cell movements: the dorsal mesoderm of the frog embryo during gastrulation as a model for the coordinated movement of connected sheets of cells and the neural crest in the chicken embryo, as a model for cell migration.Subjects--Topical Terms:

1017686
Biology, Cell.

The molecular control of cell movements during early vertebrate development.
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100 1 $a Ewald, Andrew Josef. $3 1943058
245 1 0 $a The molecular control of cell movements during early vertebrate development.
300 $a 289 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2477.
500 $a Adviser: Scott Earl Fraser.
502 $a Thesis (Ph.D.)--California Institute of Technology, 2003.
520 $a The early development of vertebrate embryos is characterized by massive, coordinated cell movements. These movements shape the embryo, distribute different cell types, shape complex tissues, and bring tissues into their correct spatial relationships. We have examined two early cell movements: the dorsal mesoderm of the frog embryo during gastrulation as a model for the coordinated movement of connected sheets of cells and the neural crest in the chicken embryo, as a model for cell migration.
520 $a The dorsal mesoderm in the frog embryo moves as a sheet of cells, due to strong connections among the cells. Cell intercalation within this sheet drives the elongation of the embryo during the process of gastrulation, whereby the round, morphologically symmetric early embryo is converted into a tadpole. We have demonstrated the existence of propagating intercellular waves of calcium within the dorsal mesoderm during gastrulation. These waves appear to be specific to the dorsal mesoderm and directly required for the cell movements of gastrulation. To build an integrated picture of how different signaling pathways interact to control gastrulation, we have developed a novel means of quantitatively imaging whole embryos with subcellular resolution. We have used this digital atlas to carefully examine the major events of gastrulation in normal embryos and embryos overexpressing a mutant form of the Disheveled protein.
520 $a The neural crest is a transient population of cells in the vertebrate embryo that arises in the neural tube and migrates to give rise to neurons, glia, bone and other cell types. During migration individual neural crest cells make extensive temporary connections with other cells, but migrate as individuals, rather than as a connected sheet. We have used patterned substrates and optical tweezers to present them with carefully controlled molecular stimuli. We have characterized their normal cellular behaviors and their response to ephrin-B ligands in a spatially and temporally defined manner.
590 $a School code: 0037.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Anatomy. $3 1021727
690 $a 0379
690 $a 0287
710 2 0 $a California Institute of Technology. $3 726902
773 0 $t Dissertation Abstracts International $g 64-06B.
790 1 0 $a Fraser, Scott Earl, $e advisor
790 $a 0037
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3093480