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Development of peptide-based acyl tr...

Papaioannou, Nikolaos.

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Development of peptide-based acyl transfer catalysts and application to the enantioselective synthesis of an aziridinomitosane.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of peptide-based acyl transfer catalysts and application to the enantioselective synthesis of an aziridinomitosane./
Author:	Papaioannou, Nikolaos.
Description:	291 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0217.
Subject:	Chemistry, Organic -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3077348
ISBN:	0493978461

Development of peptide-based acyl transfer catalysts and application to the enantioselective synthesis of an aziridinomitosane.
Papaioannou, Nikolaos.

Development of peptide-based acyl transfer catalysts and application to the enantioselective synthesis of an aziridinomitosane. - 291 p.

Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0217.

Thesis (Ph.D.)--Boston College, 2003.

<italic>Chapter 1</italic>. This chapter is a brief survey of the most recent advances in the synthesis of mitosanes, mitosenes, the mitomycin natural products and FR900486. It emphasizes completed total syntheses as well as asymmetric efforts that have culminated in the synthesis of optically pure mitosanes and mitosenes.

ISBN: 0493978461Subjects--Topical Terms:

1941635
Chemistry, Organic

Development of peptide-based acyl transfer catalysts and application to the enantioselective synthesis of an aziridinomitosane.
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008 130614s2003 eng d
020 $a 0493978461
035 $a (UnM)AAI3077348
035 $a AAI3077348
040 $a UnM $c UnM
100 1 $a Papaioannou, Nikolaos. $3 1941695
245 1 0 $a Development of peptide-based acyl transfer catalysts and application to the enantioselective synthesis of an aziridinomitosane.
300 $a 291 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0217.
500 $a Adviser: Scott J. Miller.
502 $a Thesis (Ph.D.)--Boston College, 2003.
520 $a <italic>Chapter 1</italic>. This chapter is a brief survey of the most recent advances in the synthesis of mitosanes, mitosenes, the mitomycin natural products and FR900486. It emphasizes completed total syntheses as well as asymmetric efforts that have culminated in the synthesis of optically pure mitosanes and mitosenes.
520 $a <italic>Chapter 2</italic>. Nucleophile containing amino acids incorporated into short peptide sequences based on β-turn or β-hairpin motifs have been found to effect the kinetic resolution of certain alcohols by asymmetric acyl transfer. The design elements, syntheses and results obtained with these catalysts are described in this chapter.
520 $a <italic>Chapter 3</italic>. Application of a small molecule peptide catalyst to the resolution of a key secondary alcohol intermediate in a target-oriented synthesis is described highlighting the screening of a small library of peptide catalysts for identification of this catalyst. Optically pure material obtained from this process was used in an enantioselective synthesis of an aziridinomitosane. Also described herein are two strategies for the total synthesis of mitomycin C as well as the identification of a divergence point for analog synthesis.
590 $a School code: 0016.
650 4 $a Chemistry, Organic $3 1941635
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3077348