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Organization of the human brain: Dev...

Aldridge, Kristina.

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Organization of the human brain: Development, variability, and evolution.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Organization of the human brain: Development, variability, and evolution./
Author:	Aldridge, Kristina.
Description:	227 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2721.
Contained By:	Dissertation Abstracts International65-06B.
Subject:	Biology, Anatomy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3137260
ISBN:	0496844482

Organization of the human brain: Development, variability, and evolution.
Aldridge, Kristina.

Organization of the human brain: Development, variability, and evolution. - 227 p.

Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2721.

Thesis (Ph.D.)--The Johns Hopkins University, 2004.

Many studies have been performed to define traits that distinguish the human brain from the other primates. The objective of this project was to investigate patterns of neural morphological organization associated with specific biological factors, including age, gender, craniofacial developmental disturbance, and species.

ISBN: 0496844482Subjects--Topical Terms:

1021727
Biology, Anatomy.

Organization of the human brain: Development, variability, and evolution.
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100 1 $a Aldridge, Kristina. $3 1940315
245 1 0 $a Organization of the human brain: Development, variability, and evolution.
300 $a 227 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2721.
500 $a Adviser: Joan T. Richtsmeier.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2004.
520 $a Many studies have been performed to define traits that distinguish the human brain from the other primates. The objective of this project was to investigate patterns of neural morphological organization associated with specific biological factors, including age, gender, craniofacial developmental disturbance, and species.
520 $a The morphological organization of the brain was assessed through Euclidean Distance Matrix Analysis (EDMA) of 3-D landmark coordinate data collected from in vivo magnetic resonance images (MRIs). The study sample included normal adult humans, 10 species of non-human anthropoid primates, normal juvenile humans, and juvenile humans with craniosynostosis.
520 $a Results of this study show that there is a uniquely human pattern of neural morphological organization; however, aspects of this human pattern vary under the influence of age, gender, and developmental disturbance. Further, these patterns are not localized to a single region, but include many regions of the brain. First, there are patterns of aging in the human brain that are shared between males and females, as well as gender-specific patterns of aging. Second, differing patterns of neural morphological organization are identified between all non-human anthropoids and humans, between monkeys and humans, between non-human hominoids and humans, as well as between hominoid species. Finally, results show that, relative to the normal condition, the morphological organization of the brain is dysmorphic in craniosynostosis both before and after surgery. Further, the brain differs from the normal condition in a manner reflecting the altered skull shape, but there are also differences that are not reflected in the skull.
520 $a Results of this study indicate that the brain is very plastic, showing change across evolutionary time, as well as across ontogenetic and life history time periods within a species. The distinguishing features of each group assessed here are not localized to a single region, but rather reflect coordinated changes across anatomical boundaries. Thus, the evolution of brain morphology in primates is not accomplished by isolated change in any specific structure, but rather by differential changes in various regions of the brain. Finally, these results provide support for the idea that the primate skull and brain are a coordinated developmental package, rather than distinct entities.
590 $a School code: 0098.
650 4 $a Biology, Anatomy. $3 1021727
650 4 $a Anthropology, Physical. $3 877524
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710 2 0 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 65-06B.
790 1 0 $a Richtsmeier, Joan T., $e advisor
790 $a 0098
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3137260