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The emotional modulation of cognitiv...

Simpson, Joseph Rogers, Jr.

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The emotional modulation of cognitive processing: Neuroimaging studies.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The emotional modulation of cognitive processing: Neuroimaging studies./
Author:	Simpson, Joseph Rogers, Jr.
Description:	152 p.
Notes:	Source: Dissertation Abstracts International, Volume: 62-06, Section: B, page: 2628.
Contained By:	Dissertation Abstracts International62-06B.
Subject:	Psychology, Physiological. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3016271
ISBN:	0493268189

The emotional modulation of cognitive processing: Neuroimaging studies.
Simpson, Joseph Rogers, Jr.

The emotional modulation of cognitive processing: Neuroimaging studies. - 152 p.

Source: Dissertation Abstracts International, Volume: 62-06, Section: B, page: 2628.

Thesis (Ph.D.)--Washington University, 2001.

The orbital and medial prefrontal cortex (OMPFC) plays a critical role in emotional processes. Specifically, it appears to be important for the integration of cognitive and emotional information. The morphometry and neural activity of this region were examined using magnetic resonance imaging (MRI), positron emission tomography (PET) and functional MRI (fMRI).

ISBN: 0493268189Subjects--Topical Terms:

1017869
Psychology, Physiological.

The emotional modulation of cognitive processing: Neuroimaging studies.
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020 $a 0493268189
035 $a (UnM)AAI3016271
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100 1 $a Simpson, Joseph Rogers, Jr. $3 1939407
245 1 4 $a The emotional modulation of cognitive processing: Neuroimaging studies.
300 $a 152 p.
500 $a Source: Dissertation Abstracts International, Volume: 62-06, Section: B, page: 2628.
500 $a Chair: Marcus E. Raichle.
502 $a Thesis (Ph.D.)--Washington University, 2001.
520 $a The orbital and medial prefrontal cortex (OMPFC) plays a critical role in emotional processes. Specifically, it appears to be important for the integration of cognitive and emotional information. The morphometry and neural activity of this region were examined using magnetic resonance imaging (MRI), positron emission tomography (PET) and functional MRI (fMRI).
520 $a In depressed subjects, blood flow and glucose metabolism as measured with PET were reduced, relative to age- and sex-matched normal controls, in a portion of the OMPFC, the subgenual prefrontal cortex (SGPFC). Anatomical measurements made using structural MRI indicated that the volume of the SGPFC was also reduced.
520 $a Blood flow in the OMPFC was reduced in normal subjects performing a cognitive task, verb generation. Practice produced further decreases in OMPFC blood flow. Across subjects, the magnitude of this decrease was correlated with degree of improvement in task performance, with greater improvement associated with larger decreases. A subsequent behavioral study indicated that task-associated anxiety was reduced with practice.
520 $a Blood flow in the OMPFC was also reduced in normal subjects anticipating a painful electric shock. Across subjects, the magnitude of this decrease was correlated with self-reported anxiety, with lower anxiety associated with larger decreases.
520 $a Examining the OMPFC using fMRI is complicated by magnetic susceptibility artifacts. Modified fMRI sequences were examined for their ability to reduce these artifacts. The most promising modification was then used in a study of verb generation. These experiments indicated that most of the OMPFC could be successfully imaged with the standard sequence commonly used for fMRI.
520 $a An fMRI study of subjects performing a cognitive discrimination task involving the surface features of neutral and negatively-valenced pictorial stimuli was then performed. In the SGPFC, deactivation was modulated by the emotional valence of the stimuli, with larger decreases to the negative stimuli. In two other regions of the OMPFC, neural activity was increased for negative relative to neutral stimuli. Enhanced activity was also detected in subcortical limbic structures such as the substantia innominata and midbrain. These results support the hypothesis that the OMPFC plays an important role in the integration of cognitive and emotional processes in humans.
590 $a School code: 0252.
650 4 $a Psychology, Physiological. $3 1017869
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0989
690 $a 0317
710 2 0 $a Washington University. $3 1250147
773 0 $t Dissertation Abstracts International $g 62-06B.
790 1 0 $a Raichle, Marcus E., $e advisor
790 $a 0252
791 $a Ph.D.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3016271