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Targeting Helicobacter pylori with a...

Marquette, Michael J.

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Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads./
Author:	Marquette, Michael J.
Description:	98 p.
Notes:	Source: Masters Abstracts International, Volume: 42-06, page: 2155.
Contained By:	Masters Abstracts International42-06.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1420671
ISBN:	0496254197

Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads.
Marquette, Michael J.

Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads. - 98 p.

Source: Masters Abstracts International, Volume: 42-06, page: 2155.

Thesis (M.S.)--West Chester University of Pennsylvania, 2004.

The association between Helicobacter pylori (H. pylori) and gastric disease---gastritis, ulceration and carcinoma---has been recognized for some time. Because the gastrointestinal tract may be viewed as extracorporeal, a method to target delivery of an active antibiotic agent could represent a significant advance in H. pylori eradication and disease treatment. The goal of this study was to develop a model system that would allow for the specific targeting of H. pylori through the use of antibody-conjugated polymer beads. The ability of such beads to interact with H. pylori was tested by creating a macromolecular, whole-cell ELISA system. Results were assayed using alkaline phosphatase-conjugated secondary antibody and p-nitrophenyl phosphate as a developing substrate. In addition, a solution phase assay, employing acridine-orange stained H. pylori cells was utilized to examine cell-bead interactions. Results demonstrate that polymer beads conjugated with Rabbit-anti-Helicobacter pylori polyclonal antibodies specifically interact with H. pylori. Conversely, polymer beads conjugated with non-specific Rabbit IgG show a significantly reduced interaction (Student t-test p < 0.05).

ISBN: 0496254197Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads.
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020 $a 0496254197
035 $a (UnM)AAI1420671
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100 1 $a Marquette, Michael J. $3 1939364
245 1 0 $a Targeting Helicobacter pylori with antibodies: Exploring drug delivery with polymer beads.
300 $a 98 p.
500 $a Source: Masters Abstracts International, Volume: 42-06, page: 2155.
500 $a Chair: Maureen T. Knabb.
502 $a Thesis (M.S.)--West Chester University of Pennsylvania, 2004.
520 $a The association between Helicobacter pylori (H. pylori) and gastric disease---gastritis, ulceration and carcinoma---has been recognized for some time. Because the gastrointestinal tract may be viewed as extracorporeal, a method to target delivery of an active antibiotic agent could represent a significant advance in H. pylori eradication and disease treatment. The goal of this study was to develop a model system that would allow for the specific targeting of H. pylori through the use of antibody-conjugated polymer beads. The ability of such beads to interact with H. pylori was tested by creating a macromolecular, whole-cell ELISA system. Results were assayed using alkaline phosphatase-conjugated secondary antibody and p-nitrophenyl phosphate as a developing substrate. In addition, a solution phase assay, employing acridine-orange stained H. pylori cells was utilized to examine cell-bead interactions. Results demonstrate that polymer beads conjugated with Rabbit-anti-Helicobacter pylori polyclonal antibodies specifically interact with H. pylori. Conversely, polymer beads conjugated with non-specific Rabbit IgG show a significantly reduced interaction (Student t-test p < 0.05).
590 $a School code: 1265.
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Health Sciences, Pharmacy. $3 1017737
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710 2 0 $a West Chester University of Pennsylvania. $3 1939365
773 0 $t Masters Abstracts International $g 42-06.
790 1 0 $a Knabb, Maureen T., $e advisor
790 $a 1265
791 $a M.S.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1420671