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Myogenic growth during early larval ...

D'Angelo, Joel.

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Myogenic growth during early larval development in zebrafish: The role of Hedgehog signaling.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Myogenic growth during early larval development in zebrafish: The role of Hedgehog signaling./
Author:	D'Angelo, Joel.
Description:	146 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1132.
Contained By:	Dissertation Abstracts International65-03B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3127554
ISBN:	0496748181

Myogenic growth during early larval development in zebrafish: The role of Hedgehog signaling.
D'Angelo, Joel.

Myogenic growth during early larval development in zebrafish: The role of Hedgehog signaling. - 146 p.

Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1132.

Thesis (Ph.D.)--Wesleyan University, 2004.

Post-embryonic growth of the vertebrate myotome occurs by the addition of new fibers at the dorsal and ventral extremes. This type of muscle growth is termed stratified hyperplasia in teleost larvae. Both slow and fast muscle fibers in zebrafish derive from dorsal and ventral regions of the larval myotome. Chapter One focuses on the cellular mechanisms of stratified hyperplasia, specifically defining the myogenic germinal zones in zebrafish. These regions have a higher percentage of proliferating cells than the remainder of the myotome and can be identified at 24h by their position and morphology in living embryos. Consistent with these regions containing myogenic cells, muscle regulatory factors (MRFs) and small diameter fast fibers are found at the dorsal and ventral regions. I refer to these regions as myogenic germinal zones. In Chapter Three I show that myogenic germinal zones develop independently of Hedgehog signaling, as their development occurs normally in Hedgehog signaling mutants, as well as in embryos treated with the Hedgehog signaling antagonist, cyclopamine. Moreover, overexpression of Hedgehog leads to a loss of morphologically identifiable germinal zones, a lack of proliferative zones, and no small fibers at the dorsal and ventral extremes. Hedgehog overexpression also causes the loss of localized MRF expression during post-embryonic myogenesis. My results suggest that Hedgehog signaling inhibits myogenic germinal zones and stratified hyperplasia in early zebrafish larvae.

ISBN: 0496748181Subjects--Topical Terms:

1017730
Biology, Genetics.

Myogenic growth during early larval development in zebrafish: The role of Hedgehog signaling.
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500 $a Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1132.
500 $a Adviser: Stephen H. Devoto.
502 $a Thesis (Ph.D.)--Wesleyan University, 2004.
520 $a Post-embryonic growth of the vertebrate myotome occurs by the addition of new fibers at the dorsal and ventral extremes. This type of muscle growth is termed stratified hyperplasia in teleost larvae. Both slow and fast muscle fibers in zebrafish derive from dorsal and ventral regions of the larval myotome. Chapter One focuses on the cellular mechanisms of stratified hyperplasia, specifically defining the myogenic germinal zones in zebrafish. These regions have a higher percentage of proliferating cells than the remainder of the myotome and can be identified at 24h by their position and morphology in living embryos. Consistent with these regions containing myogenic cells, muscle regulatory factors (MRFs) and small diameter fast fibers are found at the dorsal and ventral regions. I refer to these regions as myogenic germinal zones. In Chapter Three I show that myogenic germinal zones develop independently of Hedgehog signaling, as their development occurs normally in Hedgehog signaling mutants, as well as in embryos treated with the Hedgehog signaling antagonist, cyclopamine. Moreover, overexpression of Hedgehog leads to a loss of morphologically identifiable germinal zones, a lack of proliferative zones, and no small fibers at the dorsal and ventral extremes. Hedgehog overexpression also causes the loss of localized MRF expression during post-embryonic myogenesis. My results suggest that Hedgehog signaling inhibits myogenic germinal zones and stratified hyperplasia in early zebrafish larvae.
590 $a School code: 0255.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Molecular. $3 1017719
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710 2 0 $a Wesleyan University. $3 1058128
773 0 $t Dissertation Abstracts International $g 65-03B.
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791 $a Ph.D.
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3127554