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Age dependent changes during the dev...

Kolar, Grant Ryan.

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Age dependent changes during the development of human B cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Age dependent changes during the development of human B cells./
Author:	Kolar, Grant Ryan.
Description:	214 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0645.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3121353
ISBN:	0496687042

Age dependent changes during the development of human B cells.
Kolar, Grant Ryan.

Age dependent changes during the development of human B cells. - 214 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0645.

Thesis (Ph.D.)--The University of Oklahoma Health Sciences Center, 2004.

As humans age the immune system undergoes distinct changes. Clinically these include decreased responses to immunizations and infections and changes including increased autoantibody prevalence in the serum among others. Many modifications to T cell differentiation and function have been reported. Far less information is available about the changes that occur in B cells. Variations in the immunoglobulin repertoire may be a result of intrinsic differences in the B cells themselves or in their developmental environment. We found that B cell progenitors from individuals of widely different ages produced nearly the same immunoglobulin repertoire when placed in the same model system. Furthermore repertoire differences were observed between primary B cell isolates from adults and neonates or children, unlike the model system. Therefore during development, factors extrinsic to B cells heavily impact the immunoglobulin repertoire. Highly specific immunoglobulin responses to pathogens are diminished with age. B cells responsible for these responses may fail to enter the germinal center compartments of peripheral lymphoid tissue, where these high affinity responses are generated, or the B cells may fail to complete the process of affinity maturation. We found that germinal center B cells decrease in an age dependent manner along with a concomitant increase in naive B cells (prior to germinal center cells in maturation) indicating that B cells have difficulty entering the germinal center reaction. Therefore, the repertoire of developing B cells is not impacted greatly by the age of their progenitors, but rather is modified by factors in the environment at the seat of their maturation. Changes in peripheral B cell phenotypes reflect difficulties entering the germinal center reaction where affinity maturation occurs. Regardless of whether these difficulties are extrinsic or intrinsic to the B cells themselves, once they enter the germinal center reaction, the molecular processes involved in the production of high affinity antibodies is preserved.

ISBN: 0496687042Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Age dependent changes during the development of human B cells.
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502 $a Thesis (Ph.D.)--The University of Oklahoma Health Sciences Center, 2004.
520 $a As humans age the immune system undergoes distinct changes. Clinically these include decreased responses to immunizations and infections and changes including increased autoantibody prevalence in the serum among others. Many modifications to T cell differentiation and function have been reported. Far less information is available about the changes that occur in B cells. Variations in the immunoglobulin repertoire may be a result of intrinsic differences in the B cells themselves or in their developmental environment. We found that B cell progenitors from individuals of widely different ages produced nearly the same immunoglobulin repertoire when placed in the same model system. Furthermore repertoire differences were observed between primary B cell isolates from adults and neonates or children, unlike the model system. Therefore during development, factors extrinsic to B cells heavily impact the immunoglobulin repertoire. Highly specific immunoglobulin responses to pathogens are diminished with age. B cells responsible for these responses may fail to enter the germinal center compartments of peripheral lymphoid tissue, where these high affinity responses are generated, or the B cells may fail to complete the process of affinity maturation. We found that germinal center B cells decrease in an age dependent manner along with a concomitant increase in naive B cells (prior to germinal center cells in maturation) indicating that B cells have difficulty entering the germinal center reaction. Therefore, the repertoire of developing B cells is not impacted greatly by the age of their progenitors, but rather is modified by factors in the environment at the seat of their maturation. Changes in peripheral B cell phenotypes reflect difficulties entering the germinal center reaction where affinity maturation occurs. Regardless of whether these difficulties are extrinsic or intrinsic to the B cells themselves, once they enter the germinal center reaction, the molecular processes involved in the production of high affinity antibodies is preserved.
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710 2 0 $a The University of Oklahoma Health Sciences Center. $3 1023966
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