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Localized surface plasmon resonance ...

Haes, Amanda Jo.

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Localized surface plasmon resonance spectroscopy for fundamental studies of nanoparticle optics and applications to biosensors.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Localized surface plasmon resonance spectroscopy for fundamental studies of nanoparticle optics and applications to biosensors./
作者:	Haes, Amanda Jo.
面頁冊數:	301 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2389.
Contained By:	Dissertation Abstracts International65-05B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3132531
ISBN:	0496797719

Localized surface plasmon resonance spectroscopy for fundamental studies of nanoparticle optics and applications to biosensors.
Haes, Amanda Jo.

Localized surface plasmon resonance spectroscopy for fundamental studies of nanoparticle optics and applications to biosensors. - 301 p.

Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2389.

Thesis (Ph.D.)--Northwestern University, 2004.

This work reveals that triangular silver nanoparticles have remarkable optical properties and that the enhanced sensitivity of their nanoenvironment can be used as a new class of optical sensors using localized surface plasmon resonance (LSPR) spectroscopy. The contents of thesis can be divided into two main subject areas: (1) the characterization and optimization of nanoparticles for the basic understanding of their optical properties and (2) the development, testing, and theoretical understanding of model biological assays and nonmodel assays for disease diagnosis. In the first half of this work, an improved understanding of the physical characteristics of noble metal nanoparticles is explored. Specifically, the realization that the sensitivity of these nanoparticles can be optimized for a given adsorbate is revealed. First, it is demonstrated that the short range (viz., 0--3 nm) distance dependence of the electromagnetic fields that surround these nanoparticles can be systematically tuned by changing their composition, size, and structure. Second, multilayer shells are assembled onto surface-confined noble metal nanoparticles to study the long range distance dependence. It is shown that this dependence (viz., 3--35 nm) is non-linear and has a tunable sensing range. Finally, methods to enhance the nanosensor's response based on interactions between the nanoparticle's plasmon resonance and the adsorbate's molecular resonance is revealed. In the remainder sections, we explore the use of these nanoparticles as biological sensors. First, the model system of biotin/streptavidin is confirmed to be highly specific with low nonspecific influences. Next, the demonstration of an immunoassay (biotin/anti-biotin) is performed. Finally, the LSPR nanosensor is shown to be a promising platform for the possible mechanistic understanding of Alzheimer's disease.

ISBN: 0496797719Subjects--Topical Terms:

586156
Chemistry, Analytical.

Localized surface plasmon resonance spectroscopy for fundamental studies of nanoparticle optics and applications to biosensors.
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