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A dynamical systems approach to esti...

Meloney, Kathleen Ann.

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A dynamical systems approach to estimating the sequences of repeat regions in the genome.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A dynamical systems approach to estimating the sequences of repeat regions in the genome./
Author:	Meloney, Kathleen Ann.
Description:	44 p.
Notes:	Source: Masters Abstracts International, Volume: 42-06, page: 2215.
Contained By:	Masters Abstracts International42-06.
Subject:	Mathematics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1419448
ISBN:	0496242180

A dynamical systems approach to estimating the sequences of repeat regions in the genome.
Meloney, Kathleen Ann.

A dynamical systems approach to estimating the sequences of repeat regions in the genome. - 44 p.

Source: Masters Abstracts International, Volume: 42-06, page: 2215.

Thesis (M.A.)--University of Maryland, College Park, 2004.

In 1982, Fred Sanger [9] introduced a cloning technique on which shotgun sequencing is based. Shotgun sequencing is a method for determining the sequence of bases (or letters) in the genome and since its introduction, many groups have used this technique to sequence the genomes of various organisms. The shotgun technique involves breaking the DNA into a large number of small pieces, each of whose sequence of letters is determined experimentally. Current technology limits the length of the sequenced pieces to approximately 500 letters. Then, like a puzzle, the pieces are assembled using computer algorithms to produce the complete sequence. The greatest difficulty with the shotgun technique is the presence of subsequences longer than 500 letters that occur multiple times in the genome with minor variations.

ISBN: 0496242180Subjects--Topical Terms:

515831
Mathematics.

A dynamical systems approach to estimating the sequences of repeat regions in the genome.
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020 $a 0496242180
035 $a (UnM)AAI1419448
035 $a AAI1419448
040 $a UnM $c UnM
100 1 $a Meloney, Kathleen Ann. $3 1935041
245 1 2 $a A dynamical systems approach to estimating the sequences of repeat regions in the genome.
300 $a 44 p.
500 $a Source: Masters Abstracts International, Volume: 42-06, page: 2215.
500 $a Chair: James A. Yorke.
502 $a Thesis (M.A.)--University of Maryland, College Park, 2004.
520 $a In 1982, Fred Sanger [9] introduced a cloning technique on which shotgun sequencing is based. Shotgun sequencing is a method for determining the sequence of bases (or letters) in the genome and since its introduction, many groups have used this technique to sequence the genomes of various organisms. The shotgun technique involves breaking the DNA into a large number of small pieces, each of whose sequence of letters is determined experimentally. Current technology limits the length of the sequenced pieces to approximately 500 letters. Then, like a puzzle, the pieces are assembled using computer algorithms to produce the complete sequence. The greatest difficulty with the shotgun technique is the presence of subsequences longer than 500 letters that occur multiple times in the genome with minor variations.
520 $a We present a dynamical systems approach to estimating the sequence of letters of these long, highly repetitive subsequences in the genome. Our results suggest that this approach produces good representatives of the long repetitive subsequences in a genome. We also present potential applications of this method to genome assembly.
590 $a School code: 0117.
650 4 $a Mathematics. $3 515831
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Computer Science. $3 626642
650 4 $a Biology, Molecular. $3 1017719
690 $a 0405
690 $a 0369
690 $a 0984
690 $a 0307
710 2 0 $a University of Maryland, College Park. $3 657686
773 0 $t Masters Abstracts International $g 42-06.
790 1 0 $a Yorke, James A., $e advisor
790 $a 0117
791 $a M.A.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1419448