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Surface thermodynamics and biophysic...

Prokop, Robert Michael.

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Surface thermodynamics and biophysics of the lung.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Surface thermodynamics and biophysics of the lung./
Author:	Prokop, Robert Michael.
Description:	207 p.
Notes:	Source: Dissertation Abstracts International, Volume: 59-06, Section: B, page: 3017.
Contained By:	Dissertation Abstracts International59-06B.
Subject:	Engineering, Mechanical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ28040
ISBN:	0612280403

Surface thermodynamics and biophysics of the lung.
Prokop, Robert Michael.

Surface thermodynamics and biophysics of the lung. - 207 p.

Source: Dissertation Abstracts International, Volume: 59-06, Section: B, page: 3017.

Thesis (Ph.D.)--University of Toronto (Canada), 1997.

This thesis applies principles and methodologies of surface thermodynamics to problems of lung physiology. In order for the muscular system to be able to perform the work of expansion and compression of the lung, the surface tension must be as low as possible. Nature facilitates this by providing a lung surfactant, consisting of a mixture of lipids and proteins, which are transported and maintained at the surface of the lung. Correct surface tension measurements of such systems have become available only very recently. These measurements have been cumbersome and based on assumptions, the correctness of which could not be guaranteed generally.

ISBN: 0612280403Subjects--Topical Terms:

783786
Engineering, Mechanical.

Surface thermodynamics and biophysics of the lung.
LDR:03112nmm 2200313 4500 001 1844765
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020 $a 0612280403
035 $a (UnM)AAINQ28040
035 $a AAINQ28040
040 $a UnM $c UnM
100 1 $a Prokop, Robert Michael. $3 1932949
245 1 0 $a Surface thermodynamics and biophysics of the lung.
300 $a 207 p.
500 $a Source: Dissertation Abstracts International, Volume: 59-06, Section: B, page: 3017.
500 $a Adviser: A. W. Neumann.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 1997.
520 $a This thesis applies principles and methodologies of surface thermodynamics to problems of lung physiology. In order for the muscular system to be able to perform the work of expansion and compression of the lung, the surface tension must be as low as possible. Nature facilitates this by providing a lung surfactant, consisting of a mixture of lipids and proteins, which are transported and maintained at the surface of the lung. Correct surface tension measurements of such systems have become available only very recently. These measurements have been cumbersome and based on assumptions, the correctness of which could not be guaranteed generally.
520 $a In order to overcome the current difficulties, a methodology, Axisymmetric Drop Shape Analysis-Captive Bubble (ADSA-CB), was developed for surface tension measurement. This new technique allows mimicking of the periodic inflation and deflation of the lung while measuring thousands of surface tension values in a very short time. With this technique, the so-called "squeeze-out" and film collapse phenomena were examined closely.
520 $a An important aspect of lung surfactant is the fact that, ultimately, the surface film will be composed almost exclusively of lipids, mostly dipalmitoyl phosphatidyl choline (DPPC). By means of an ADSA study on the DPPC monolayer, a mechanism of lipid arrangement at the surface was proposed: gaseous phase, gradual transition from gaseous to liquid-condensed and to solid phase, and solid phase.
520 $a To develop expressions for the key performance measures of lungs, such as surface area, distortion energy and mechanical work, in terms of measurable quantities, a thermodynamic model of the lung has been developed: Starting with a general thermodynamic expression for the distortion energy, a relation between the recoil pressure and the surface tension was found. Using the properties of partial derivatives, a general expression for the surface area was derived. For the two separate cases: (1) lungs with constant surface tension and (2) air-filled lungs, explicit expressions for the distortion energy and mechanical work were obtained. The model predictions are in good agreement with the experiment in all situations.
590 $a School code: 0779.
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Biophysics, General. $3 1019105
690 $a 0548
690 $a 0786
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Dissertation Abstracts International $g 59-06B.
790 1 0 $a Neumann, A. W., $e advisor
790 $a 0779
791 $a Ph.D.
792 $a 1997
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ28040