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Functional cardiac magnetic resonanc...

Brau, Anja Christina Sophie.

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Functional cardiac magnetic resonance microscopy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Functional cardiac magnetic resonance microscopy./
Author:	Brau, Anja Christina Sophie.
Description:	129 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 3021.
Contained By:	Dissertation Abstracts International65-06B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3135122
ISBN:	0496823469

Functional cardiac magnetic resonance microscopy.
Brau, Anja Christina Sophie.

Functional cardiac magnetic resonance microscopy. - 129 p.

Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 3021.

Thesis (Ph.D.)--Duke University, 2003.

The study of small animal models of human cardiovascular disease is critical to our understanding of the origin, progression, and treatment of this pervasive disease. Complete analysis of disease pathophysiology in these animal models requires measuring structural and functional changes at the level of the whole heart---a task for which an appropriate non-invasive imaging method is needed. The purpose of this work was thus to develop an imaging technique to support in vivo characterization of cardiac structure and function in rat and mouse models of cardiovascular disease.

ISBN: 0496823469Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Functional cardiac magnetic resonance microscopy.
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100 1 $a Brau, Anja Christina Sophie. $3 1932745
245 1 0 $a Functional cardiac magnetic resonance microscopy.
300 $a 129 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 3021.
500 $a Adviser: G. Allan Johnson.
502 $a Thesis (Ph.D.)--Duke University, 2003.
520 $a The study of small animal models of human cardiovascular disease is critical to our understanding of the origin, progression, and treatment of this pervasive disease. Complete analysis of disease pathophysiology in these animal models requires measuring structural and functional changes at the level of the whole heart---a task for which an appropriate non-invasive imaging method is needed. The purpose of this work was thus to develop an imaging technique to support in vivo characterization of cardiac structure and function in rat and mouse models of cardiovascular disease.
520 $a Whereas clinical cardiac magnetic resonance imaging (MRI) provides accurate assessment of the human heart, the extension of cardiac MRI from humans to rodents presents several formidable scaling challenges. Acquiring images of the mouse heart with organ definition and fluidity of contraction comparable to that achieved in humans requires an increase in spatial resolution by a factor of 3000 and an increase in temporal resolution by a factor of ten. No single technical innovation can meet the demanding imaging requirements imposed by the small animal.
520 $a A functional cardiac magnetic resonance microscopy technique was developed by integrating improvements in physiological control, imaging hardware, biological synchronization of imaging, and pulse sequence design to achieve high-quality images of the murine heart with high spatial and temporal resolution. The specific methods and results from three different sets of imaging experiments are presented: (1) 2D functional imaging in the rat with spatial resolution of 175 mum2 x 1 mm and temporal resolution of 10 ms; (2) 3D functional imaging in the rat with spatial resolution of 100 mum 2 x 500 mum and temporal resolution of 30 ms; and (3) 2D functional imaging in the mouse with spatial resolution down to 100 mum2 x 1 mm and temporal resolution of 10 ms.
520 $a The cardiac microscopy technique presented here represents a novel collection of technologies capable of acquiring routine high-quality images of murine cardiac structure and function with minimal artifacts and markedly higher spatial resolution compared to conventional techniques. This work is poised to serve a valuable role in the evaluation of cardiovascular disease and should find broad application in studies ranging from basic pathophysiology to drug discovery.
590 $a School code: 0066.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Radiology. $3 1019076
650 4 $a Physics, General. $3 1018488
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710 2 0 $a Duke University. $3 569686
773 0 $t Dissertation Abstracts International $g 65-06B.
790 1 0 $a Johnson, G. Allan, $e advisor
790 $a 0066
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3135122