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Adaptive real-time closed-loop tempe...

Sun, Lei.

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Adaptive real-time closed-loop temperature control for ultrasound hyperthermia using magnetic resonance thermometry.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Adaptive real-time closed-loop temperature control for ultrasound hyperthermia using magnetic resonance thermometry./
Author:	Sun, Lei.
Description:	193 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3570.
Contained By:	Dissertation Abstracts International65-07B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3140086
ISBN:	0496872273

Adaptive real-time closed-loop temperature control for ultrasound hyperthermia using magnetic resonance thermometry.
Sun, Lei.

Adaptive real-time closed-loop temperature control for ultrasound hyperthermia using magnetic resonance thermometry. - 193 p.

Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3570.

Thesis (Ph.D.)--The Pennsylvania State University, 2004.

Hyperthermia, to elevate the target tissue temperature above 43°C for over half an hour and have the temperature less than 41°C outside the region of interest, can significantly improve the tumor treatment when associated with radio- or chemo-therapy.

ISBN: 0496872273Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Adaptive real-time closed-loop temperature control for ultrasound hyperthermia using magnetic resonance thermometry.
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245 1 0 $a Adaptive real-time closed-loop temperature control for ultrasound hyperthermia using magnetic resonance thermometry.
300 $a 193 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3570.
502 $a Thesis (Ph.D.)--The Pennsylvania State University, 2004.
520 $a Hyperthermia, to elevate the target tissue temperature above 43°C for over half an hour and have the temperature less than 41°C outside the region of interest, can significantly improve the tumor treatment when associated with radio- or chemo-therapy.
520 $a To accomplish the hyperthermia treatment, one key issue is to automatically regulate the temperature elevation to satisfy the treatment requirement. In this research, by proposing and applying self-tuning regulator (STR) and model reference adaptive control (MRAC) methods with an intracavitary ultrasound array system, we demonstrated the capability of these adaptive temperature controls to stably increase the tissue temperature to therapeutic level facing dynamic tissue parameters such as blood perfusion. Computer simulations displayed that both methods did not require a priori knowledge of the tissue properties and adaptively change the amplitudes and phases of the array's driving signal according to the blood perfusion and other dynamic tissue properties to heat up the target tissue to 43 +/- 0.1°C within 6 +/- 0.1 minutes. Further ex vivo and in vivo experiments with invasive measurement (using fiber optic thermometer) showed that both bovine muscle and rabbit thigh temperatures were increase by 8 +/- 0.2°C within 7 +/- 0.2 minutes.
520 $a Additionally, a non-invasive magnetic resonance imaging (MRI) technique using the proton resonant frequency shift was implemented to provide 2-D or 3-D quantitative temperature feedback for the ultrasound hyerpthermia treatment. MRI also allows for the alignment of the ultrasound applicator with respect to the target tumor tissue. The STR and MRAC temperature control methods together with MRI thermometry were applied for non-invasive hyperthermia treatment. The ex vivo experiments with bovine muscles show that starting at an initial temperature of 28°C, the controller achieves the steady state temperature within 6 +/- 0.5 minutes; deviation from the target profile no greater than +/-1.37°C. Similar to the ex vivo results, the in vivo experimental results using New Zealand white rabbits indicate that the rabbit thigh muscle is heated initially from 36.5°C to the target temperature 44.5°C for 25 minutes and the transitional period is within 8.0 +/- 0.6 minutes. The maximum variation from the desired temperature profile is less than 2.5°C; after reaching steady state, tissue temperature is maintained at 44.5°C +/- 1.2°C.
520 $a The overall simulation and experiment results indicate the feasibility and effectiveness of using STR and MRAC adaptive temperature control methods for ultrasound hyperthermia treatment. Using MRI thermometry, it is promising for a completely non-invasive hyperthermia treatment.
590 $a School code: 0176.
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0541
710 2 0 $a The Pennsylvania State University. $3 699896
773 0 $t Dissertation Abstracts International $g 65-07B.
790 $a 0176
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3140086