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The epidemiologic analysis of lympha...

Tisch, Daniel James.

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The epidemiologic analysis of lymphatic filariasis control.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The epidemiologic analysis of lymphatic filariasis control./
Author:	Tisch, Daniel James.
Description:	202 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2176.
Contained By:	Dissertation Abstracts International65-05B.
Subject:	Biology, Biostatistics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3132842
ISBN:	0496800825

The epidemiologic analysis of lymphatic filariasis control.
Tisch, Daniel James.

The epidemiologic analysis of lymphatic filariasis control. - 202 p.

Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2176.

Thesis (Ph.D.)--Case Western Reserve University (Health Sciences), 2004.

Wuchereria bancrofti currently infects 128 million people globally, leading to an estimated 43 million cases of overt lymphatic pathology. Shortly following the development of improved diagnostic tests and mass drug therapies, The World Health Organization (WHO) classified this parasite as one of six currently eradicable diseases and initiated The Program to Eliminate Lymphatic Filariasis, combining the efforts or industry, academia, non-governmental, and governmental organizations for the purpose of halting transmission and treating disease. This dissertation integrates existing and new information into the most robust and accurate estimates of drug treatment efficacies in individuals and populations. In the first aim, all known drug efficacy trials are systematically reviewed using meta-analytic statistical techniques. Summary estimates of microfilaria elimination are calculated for each available drug, dose, and treatment schedule. The second aim validates a filariasis transmission model with data from Papua New Guinea to determine the generalizability of the model for an area of unusually high parasite transmission. The results and conclusions from this dissertation are applicable to the international effort to eliminate lymphatic filariasis and should aid future analytic development in this field, particularly with the potential to combine the estimates of drug effect in Aim I with the validated model in Aim II for the design and evaluation of programs to control lymphatic filariasis in Papua New Guinea.

ISBN: 0496800825Subjects--Topical Terms:

1018416
Biology, Biostatistics.

The epidemiologic analysis of lymphatic filariasis control.
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245 1 4 $a The epidemiologic analysis of lymphatic filariasis control.
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500 $a Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2176.
500 $a Adviser: Christopher Whalen.
502 $a Thesis (Ph.D.)--Case Western Reserve University (Health Sciences), 2004.
520 $a Wuchereria bancrofti currently infects 128 million people globally, leading to an estimated 43 million cases of overt lymphatic pathology. Shortly following the development of improved diagnostic tests and mass drug therapies, The World Health Organization (WHO) classified this parasite as one of six currently eradicable diseases and initiated The Program to Eliminate Lymphatic Filariasis, combining the efforts or industry, academia, non-governmental, and governmental organizations for the purpose of halting transmission and treating disease. This dissertation integrates existing and new information into the most robust and accurate estimates of drug treatment efficacies in individuals and populations. In the first aim, all known drug efficacy trials are systematically reviewed using meta-analytic statistical techniques. Summary estimates of microfilaria elimination are calculated for each available drug, dose, and treatment schedule. The second aim validates a filariasis transmission model with data from Papua New Guinea to determine the generalizability of the model for an area of unusually high parasite transmission. The results and conclusions from this dissertation are applicable to the international effort to eliminate lymphatic filariasis and should aid future analytic development in this field, particularly with the potential to combine the estimates of drug effect in Aim I with the validated model in Aim II for the design and evaluation of programs to control lymphatic filariasis in Papua New Guinea.
590 $a School code: 0499.
650 4 $a Biology, Biostatistics. $3 1018416
650 4 $a Health Sciences, Public Health. $3 1017659
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