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Limb differences in vascular functio...

Newcomer, Sean C.

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Limb differences in vascular function: Effects of age and endurance training.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Limb differences in vascular function: Effects of age and endurance training./
Author:	Newcomer, Sean C.
Description:	102 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4360.
Contained By:	Dissertation Abstracts International65-09B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3147662
ISBN:	0496067524

Limb differences in vascular function: Effects of age and endurance training.
Newcomer, Sean C.

Limb differences in vascular function: Effects of age and endurance training. - 102 p.

Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4360.

Thesis (Ph.D.)--The Pennsylvania State University, 2004.

Background. Forearm endothelium-dependent vasodilation is impaired with age in sedentary, but not endurance-trained men. The purpose of this investigation was to determine if these age and physical activity related differences in endothelium-dependent vasodilation also occur in the leg.

ISBN: 0496067524Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Limb differences in vascular function: Effects of age and endurance training.
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035 $a (UnM)AAI3147662
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040 $a UnM $c UnM
100 1 $a Newcomer, Sean C. $3 1931343
245 1 0 $a Limb differences in vascular function: Effects of age and endurance training.
300 $a 102 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4360.
500 $a Adviser: David N. Proctor.
502 $a Thesis (Ph.D.)--The Pennsylvania State University, 2004.
520 $a Background. Forearm endothelium-dependent vasodilation is impaired with age in sedentary, but not endurance-trained men. The purpose of this investigation was to determine if these age and physical activity related differences in endothelium-dependent vasodilation also occur in the leg.
520 $a Methods and results. Brachial and common femoral arterial blood flow were measured using Doppler ultrasound during increasing doses of acetylcholine (1, 4, and 16 mug/100 ml of limb tissue/min), substance P (8, 31, and 125 mug/100 ml of limb tissue/min), and sodium nitroprusside (0.063, 0.25, and 1 mug/100 ml of limb tissue/min) in 23 healthy men (8 younger sedentary, 8 older sedentary, and 7 older endurance-trained). Increases in forearm blood flow to the highest dose of acetylcholine and sodium nitroprusside were less (P < 0.05) in older sedentary (841 +/- 142%, 428 +/- 74%) compared to younger sedentary (1519 +/- 256%, 925 +/- 163%) subjects. Similarly, increases in forearm blood flow to sodium nitroprusside (1 mug/100 ml of limb tissue/min) were less (P < 0.05) in older endurance-trained (505 +/- 110%) compared to younger sedentary (925 +/- 163%) subjects. In contrast, no differences in leg blood flow responses to intra-arterial infusions of acetylcholine, substance P, or sodium nitroprusside were noted between subject groups.
520 $a Conclusions. These results demonstrate that endothelial and vascular smooth muscle vasodilator function are preserved in the leg vasculature of older sedentary and endurance-trained men. Moreover, these findings demonstrate that aging and endurance training heterogeneously influence peripheral vascular function.
590 $a School code: 0176.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Recreation. $3 1018003
690 $a 0433
690 $a 0575
710 2 0 $a The Pennsylvania State University. $3 699896
773 0 $t Dissertation Abstracts International $g 65-09B.
790 1 0 $a Proctor, David N., $e advisor
790 $a 0176
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3147662