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Exercise induced muscle damage: Pla...

Lee, Joohyung.

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Exercise induced muscle damage: Plasma glutathione, creatine kinase activity, and gene expression profiling of neutrophils.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Exercise induced muscle damage: Plasma glutathione, creatine kinase activity, and gene expression profiling of neutrophils./
Author:	Lee, Joohyung.
Description:	185 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2902.
Contained By:	Dissertation Abstracts International65-06B.
Subject:	Health Sciences, Recreation. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3136749
ISBN:	0496839454

Exercise induced muscle damage: Plasma glutathione, creatine kinase activity, and gene expression profiling of neutrophils.
Lee, Joohyung.

Exercise induced muscle damage: Plasma glutathione, creatine kinase activity, and gene expression profiling of neutrophils. - 185 p.

Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2902.

Thesis (Ph.D.)--University of Massachusetts Amherst, 2004.

Eccentric muscle contractions induce ultrastructural disruption, prolonged loss of maximal strength (MVC) and range of motion (ROM), increase in muscle soreness (SOR) and muscle proteins, and secondary damage by inflammation. The overall purpose of this dissertation research was to further examine the relationship between blood glutathione (GSH) levels and the blood creatine kinase (CK) response to eccentric exercise, and the inflammatory response, specifically neutrophil function.

ISBN: 0496839454Subjects--Topical Terms:

1018003
Health Sciences, Recreation.

Exercise induced muscle damage: Plasma glutathione, creatine kinase activity, and gene expression profiling of neutrophils.
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100 1 $a Lee, Joohyung. $3 1931322
245 1 0 $a Exercise induced muscle damage: Plasma glutathione, creatine kinase activity, and gene expression profiling of neutrophils.
300 $a 185 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-06, Section: B, page: 2902.
500 $a Director: Priscilla M. Clarkson.
502 $a Thesis (Ph.D.)--University of Massachusetts Amherst, 2004.
520 $a Eccentric muscle contractions induce ultrastructural disruption, prolonged loss of maximal strength (MVC) and range of motion (ROM), increase in muscle soreness (SOR) and muscle proteins, and secondary damage by inflammation. The overall purpose of this dissertation research was to further examine the relationship between blood glutathione (GSH) levels and the blood creatine kinase (CK) response to eccentric exercise, and the inflammatory response, specifically neutrophil function.
520 $a Study I examined the effect of resting GSH levels on CK activity after eccentric muscle contractions, and Study II examined the effect of alpha-lipoic acid (LA) supplementation on resting GSH levels in plasma. Study III examined the effect of eccentric muscle contractions on neutrophil function by examining gene expression of neutrophils after eccentric muscle contractions to determine which genes are up-regulated or down-regulated during initiation of inflammation. It was concluded from Study I that subjects in the low GSH group experienced less muscle damage than subjects in the high GSH group, and these changes for the low GSH group were consistent with less secondary damage due to inflammation. Study II concluded that LA supplementation for 4 weeks may not be enough to increase GSH levels in low GSH group. Study III concluded that neutrophils initiate several processes including inflammation, cytoskeletal regulation, transcription, and metabolism in response to eccentric muscle contractions with the evidence of up- or down-regulation of genes.
590 $a School code: 0118.
650 4 $a Health Sciences, Recreation. $3 1018003
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0575
690 $a 0433
710 2 0 $a University of Massachusetts Amherst. $3 1019433
773 0 $t Dissertation Abstracts International $g 65-06B.
790 1 0 $a Clarkson, Priscilla M., $e advisor
790 $a 0118
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3136749