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Effects of exercise with and without...

Warner, Sarah Elizabeth Rogers.

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Effects of exercise with and without weight bearing on bone architecture and strength.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of exercise with and without weight bearing on bone architecture and strength./
Author:	Warner, Sarah Elizabeth Rogers.
Description:	88 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4709.
Contained By:	Dissertation Abstracts International64-10B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3110125
ISBN:	049657664X

Effects of exercise with and without weight bearing on bone architecture and strength.
Warner, Sarah Elizabeth Rogers.

Effects of exercise with and without weight bearing on bone architecture and strength. - 88 p.

Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4709.

Thesis (Ph.D.)--The University of Utah, 2003.

Previous research has provided evidence to suggest that both weight bearing and non-weight-bearing exercise are beneficial for bone health. The mechanism of these bone adaptations is unclear but may be influenced by skeletal muscle, presence of estrogen, or forces due to mechanical loading. This dissertation includes three main objectives: (a) to assess adaptations in femur mineral content, cortical structure and bone strength in response to swim training in intact and ovariectomized rats; (b) to compare the timing of adaptations in skeletal muscle across swimming and uphill treadmill training at 4-week intervals during a 12-week trial and to evaluate the relationship between indices of hind limb skeletal muscle size and femur mechanical strength; and (c) to compare femur bone mineral density (BMD) and mechanical strength differences in response to weight bearing and non-weight-bearing exercise. A total of seventy-five 120-day-old female Sprague-Dawley rats were used for two interventions: swimming (n = 45) and treadmill ( n = 30). The swim phase rats were randomized into five groups: baseline (BL; n = 10), sham control (SCs; n = 8), sham swim (SS: n = 8), ovariectomized control (OCs; n = 9), ovariectomized swim (OS; n = 10). The treadmill phase included three groups: baseline (BL; n = 10), sham control (SCt; n = 10), and sham treadmill (ST; n = 10). Swimming and uphill treadmill exercise progressed to 1 hour a day, 5 days a week for 12 weeks. Swimming was associated with improved femur cortical area and cortical BMD relative to nonexercising controls, but was not associated with significant differences in bone strength in estrogen deplete and replete rats. Hind leg lean mass and muscle CSA was greater for treadmill trained rats than swimmers after 4--8 weeks of training and remained higher through 12-weeks of exercise. Muscle size was not a significant predictor of femur bone material or whole bone mechanical properties. Neither BMD nor bone mechanical strength was altered by swimming or treadmill exercise in intact rats after 12 weeks of exercise. Although treadmill training was associated with earlier increases in hind limb skeletal muscle size, swimming exercise appeared to be more effective at improving structural properties of the femur in skeletally robust virgin female rats.

ISBN: 049657664XSubjects--Topical Terms:

1017835
Biology, Animal Physiology.

Effects of exercise with and without weight bearing on bone architecture and strength.
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100 1 $a Warner, Sarah Elizabeth Rogers. $3 1931278
245 1 0 $a Effects of exercise with and without weight bearing on bone architecture and strength.
300 $a 88 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4709.
500 $a Adviser: Janet M. Shaw.
502 $a Thesis (Ph.D.)--The University of Utah, 2003.
520 $a Previous research has provided evidence to suggest that both weight bearing and non-weight-bearing exercise are beneficial for bone health. The mechanism of these bone adaptations is unclear but may be influenced by skeletal muscle, presence of estrogen, or forces due to mechanical loading. This dissertation includes three main objectives: (a) to assess adaptations in femur mineral content, cortical structure and bone strength in response to swim training in intact and ovariectomized rats; (b) to compare the timing of adaptations in skeletal muscle across swimming and uphill treadmill training at 4-week intervals during a 12-week trial and to evaluate the relationship between indices of hind limb skeletal muscle size and femur mechanical strength; and (c) to compare femur bone mineral density (BMD) and mechanical strength differences in response to weight bearing and non-weight-bearing exercise. A total of seventy-five 120-day-old female Sprague-Dawley rats were used for two interventions: swimming (n = 45) and treadmill ( n = 30). The swim phase rats were randomized into five groups: baseline (BL; n = 10), sham control (SCs; n = 8), sham swim (SS: n = 8), ovariectomized control (OCs; n = 9), ovariectomized swim (OS; n = 10). The treadmill phase included three groups: baseline (BL; n = 10), sham control (SCt; n = 10), and sham treadmill (ST; n = 10). Swimming and uphill treadmill exercise progressed to 1 hour a day, 5 days a week for 12 weeks. Swimming was associated with improved femur cortical area and cortical BMD relative to nonexercising controls, but was not associated with significant differences in bone strength in estrogen deplete and replete rats. Hind leg lean mass and muscle CSA was greater for treadmill trained rats than swimmers after 4--8 weeks of training and remained higher through 12-weeks of exercise. Muscle size was not a significant predictor of femur bone material or whole bone mechanical properties. Neither BMD nor bone mechanical strength was altered by swimming or treadmill exercise in intact rats after 12 weeks of exercise. Although treadmill training was associated with earlier increases in hind limb skeletal muscle size, swimming exercise appeared to be more effective at improving structural properties of the femur in skeletally robust virgin female rats.
590 $a School code: 0240.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Recreation. $3 1018003
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710 2 0 $a The University of Utah. $3 1017410
773 0 $t Dissertation Abstracts International $g 64-10B.
790 1 0 $a Shaw, Janet M., $e advisor
790 $a 0240
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3110125