東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Modulation of gut immune function in...

Dalloul, Rami Ali.

Linked to FindBook

Google Book

Amazon

博客來

Modulation of gut immune function in chickens.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Modulation of gut immune function in chickens./
Author:	Dalloul, Rami Ali.
Description:	174 p.
Notes:	Source: Dissertation Abstracts International, Volume: 63-06, Section: B, page: 2664.
Contained By:	Dissertation Abstracts International63-06B.
Subject:	Agriculture, Animal Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3055562
ISBN:	0493711503

Modulation of gut immune function in chickens.
Dalloul, Rami Ali.

Modulation of gut immune function in chickens. - 174 p.

Source: Dissertation Abstracts International, Volume: 63-06, Section: B, page: 2664.

Thesis (Ph.D.)--University of Maryland, College Park, 2002.

Studies were conducted to test the hypothesis altering intestinal immune function in broiler chickens affects health and susceptibility to diseases. Treatments tested included vitamin A deficiency (negative modulation), Lactobacillus-based probiotic stimulation (positive modulation), and their combination. Vitamin A deficiency impaired gut-associated lymphoid tissues (GALT) with an effect best characterized as a reduction in intraepithelial lymphocyte (IEL) subpopulations, mainly CD4+ T cells. This change in IEL lowered resistance to Eimeria acervulina infection, resulting in greater oocyst shedding. Systemic immunity (e.g., interferon-gamma (IFN-gamma) secretion and ability of splenic T lymphocytes to respond to in vitro mitogen) was also impaired. Lactobacillus-based probiotic increased certain IEL subpopulations within the GALT, namely the main effector immune cells CD4+ and CD8+ T cells. The probiotic also stimulated early cellular immune responses against E. acervulina (e.g., IFN-gamma and interleukin-2 (IL-2)). The probiotic also provided protection to different inoculation rates of E. acervulina pathogen as manifested by lower oocyst shedding. In experiments with combined treatments, the probiotic had immunostimulatory effects even in birds compromised by a hypovitaminosis A as evidenced by lower oocyst shedding and higher IFN-gamma and IL-2 levels in probiotic birds compared to controls or vitamin A-deficient birds. Humoral response to E. acervulina was unaffected by probiotic. Collectively, the project showed clear evidence of the immunostimulatory actions of a Lactobacillus-based probiotic, which enhanced immunity against an enteric disease and an immunosuppressive agent in broiler chickens. The research also expanded basic understanding of the function of gut mucosal immunity in broiler chickens and the underlying immunological changes associated with probiotic treatment. Further, given the economic impact of infectious enteric diseases in modern poultry production, probiotic supplementation offers a simple way to maintain normal beneficial microflora and enhance the birds' resistance to enteric infections, and, thereby, providing an additional tool for reducing morbidity and mortality caused by such infections.

ISBN: 0493711503Subjects--Topical Terms:

1021764
Agriculture, Animal Pathology.

Modulation of gut immune function in chickens.
LDR:03129nmm 2200277 4500 001 1841312
005 20050908073015.5
008 130614s2002 eng d
020 $a 0493711503
035 $a (UnM)AAI3055562
035 $a AAI3055562
040 $a UnM $c UnM
100 1 $a Dalloul, Rami Ali. $3 1929617
245 1 0 $a Modulation of gut immune function in chickens.
300 $a 174 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-06, Section: B, page: 2664.
500 $a Chair: John A. Doerr.
502 $a Thesis (Ph.D.)--University of Maryland, College Park, 2002.
520 $a Studies were conducted to test the hypothesis altering intestinal immune function in broiler chickens affects health and susceptibility to diseases. Treatments tested included vitamin A deficiency (negative modulation), Lactobacillus-based probiotic stimulation (positive modulation), and their combination. Vitamin A deficiency impaired gut-associated lymphoid tissues (GALT) with an effect best characterized as a reduction in intraepithelial lymphocyte (IEL) subpopulations, mainly CD4+ T cells. This change in IEL lowered resistance to Eimeria acervulina infection, resulting in greater oocyst shedding. Systemic immunity (e.g., interferon-gamma (IFN-gamma) secretion and ability of splenic T lymphocytes to respond to in vitro mitogen) was also impaired. Lactobacillus-based probiotic increased certain IEL subpopulations within the GALT, namely the main effector immune cells CD4+ and CD8+ T cells. The probiotic also stimulated early cellular immune responses against E. acervulina (e.g., IFN-gamma and interleukin-2 (IL-2)). The probiotic also provided protection to different inoculation rates of E. acervulina pathogen as manifested by lower oocyst shedding. In experiments with combined treatments, the probiotic had immunostimulatory effects even in birds compromised by a hypovitaminosis A as evidenced by lower oocyst shedding and higher IFN-gamma and IL-2 levels in probiotic birds compared to controls or vitamin A-deficient birds. Humoral response to E. acervulina was unaffected by probiotic. Collectively, the project showed clear evidence of the immunostimulatory actions of a Lactobacillus-based probiotic, which enhanced immunity against an enteric disease and an immunosuppressive agent in broiler chickens. The research also expanded basic understanding of the function of gut mucosal immunity in broiler chickens and the underlying immunological changes associated with probiotic treatment. Further, given the economic impact of infectious enteric diseases in modern poultry production, probiotic supplementation offers a simple way to maintain normal beneficial microflora and enhance the birds' resistance to enteric infections, and, thereby, providing an additional tool for reducing morbidity and mortality caused by such infections.
590 $a School code: 0117.
650 4 $a Agriculture, Animal Pathology. $3 1021764
650 4 $a Agriculture, Animal Culture and Nutrition. $3 1017857
690 $a 0476
690 $a 0475
710 2 0 $a University of Maryland, College Park. $3 657686
773 0 $t Dissertation Abstracts International $g 63-06B.
790 1 0 $a Doerr, John A., $e advisor
790 $a 0117
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3055562