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Studies in biological surface scienc...

Holden, Matthew Alexander.

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Studies in biological surface science: Microfluidics, photopatterning and artificial bilayers.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Studies in biological surface science: Microfluidics, photopatterning and artificial bilayers./
Author:	Holden, Matthew Alexander.
Description:	108 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2389.
Contained By:	Dissertation Abstracts International65-05B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3132091
ISBN:	0496793317

Studies in biological surface science: Microfluidics, photopatterning and artificial bilayers.
Holden, Matthew Alexander.

Studies in biological surface science: Microfluidics, photopatterning and artificial bilayers. - 108 p.

Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2389.

Thesis (Ph.D.)--Texas A&M University, 2004.

Herein is presented the collective experimental record of research performed in the Laboratory for Biological Surface Science. These investigations are generally classified under the category of bioanalytical surface science and include the following projects. Chapters III and IV describe the creation of a microfluidic device capable of generating fixed arrays of concentration gradients. Experimental results were matched with computational fluid dynamics simulations to predict analyte distributions in these systems. Chapters V and VI demonstrate the discovery and utility of photobleaching fluorophores for micropatterning applications. Bleached fluorophores were found to rapidly attach to electron rich surfaces and this property was used to pattern enzymes inside microfluidic channels in situ. Finally, Chapter VII exhibits a method by which solid supported lipid bilayers can be dried and preserved by specifically bound proteins. The intrinsic property of lateral lipid mobility was maintained during this process and a mechanism by which the protein protects the bilayer was suggested.

ISBN: 0496793317Subjects--Topical Terms:

586156
Chemistry, Analytical.

Studies in biological surface science: Microfluidics, photopatterning and artificial bilayers.
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100 1 $a Holden, Matthew Alexander. $3 1928694
245 1 0 $a Studies in biological surface science: Microfluidics, photopatterning and artificial bilayers.
300 $a 108 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2389.
500 $a Chair: Paul S. Cremer.
502 $a Thesis (Ph.D.)--Texas A&M University, 2004.
520 $a Herein is presented the collective experimental record of research performed in the Laboratory for Biological Surface Science. These investigations are generally classified under the category of bioanalytical surface science and include the following projects. Chapters III and IV describe the creation of a microfluidic device capable of generating fixed arrays of concentration gradients. Experimental results were matched with computational fluid dynamics simulations to predict analyte distributions in these systems. Chapters V and VI demonstrate the discovery and utility of photobleaching fluorophores for micropatterning applications. Bleached fluorophores were found to rapidly attach to electron rich surfaces and this property was used to pattern enzymes inside microfluidic channels in situ. Finally, Chapter VII exhibits a method by which solid supported lipid bilayers can be dried and preserved by specifically bound proteins. The intrinsic property of lateral lipid mobility was maintained during this process and a mechanism by which the protein protects the bilayer was suggested.
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650 4 $a Chemistry, Analytical. $3 586156
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710 2 0 $a Texas A&M University. $3 718977
773 0 $t Dissertation Abstracts International $g 65-05B.
790 1 0 $a Cremer, Paul S., $e advisor
790 $a 0803
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