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Major Histocompatibility Complex cla...

Murray, Brent William.

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Major Histocompatibility Complex class II sequence variation in cetaceans: DQ(beta) and DR(beta) variation in beluga (Delphinapterus leucas) and DQ(beta) variation in north atlantic right whales (Eubalaena glacialis).

Record Type:	Electronic resources : Monograph/item
Title/Author:	Major Histocompatibility Complex class II sequence variation in cetaceans: DQ(beta) and DR(beta) variation in beluga (Delphinapterus leucas) and DQ(beta) variation in north atlantic right whales (Eubalaena glacialis)./
Author:	Murray, Brent William.
Description:	164 p.
Notes:	Source: Dissertation Abstracts International, Volume: 59-08, Section: B, page: 3870.
Contained By:	Dissertation Abstracts International59-08B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ30162
ISBN:	0612301621

Major Histocompatibility Complex class II sequence variation in cetaceans: DQ(beta) and DR(beta) variation in beluga (Delphinapterus leucas) and DQ(beta) variation in north atlantic right whales (Eubalaena glacialis).
Murray, Brent William.

Major Histocompatibility Complex class II sequence variation in cetaceans: DQ(beta) and DR(beta) variation in beluga (Delphinapterus leucas) and DQ(beta) variation in north atlantic right whales (Eubalaena glacialis). - 164 p.

Source: Dissertation Abstracts International, Volume: 59-08, Section: B, page: 3870.

Thesis (Ph.D.)--McMaster University (Canada), 1997.

00) of beluga (Delphinapterus leucas) and a sample (Allelic variation at the Major Histocompatibility Complex (Mhc) class II loci

ISBN: 0612301621Subjects--Topical Terms:

1017730
Biology, Genetics.

Major Histocompatibility Complex class II sequence variation in cetaceans: DQ(beta) and DR(beta) variation in beluga (Delphinapterus leucas) and DQ(beta) variation in north atlantic right whales (Eubalaena glacialis).
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100 1 $a Murray, Brent William. $3 1927866
245 1 0 $a Major Histocompatibility Complex class II sequence variation in cetaceans: DQ(beta) and DR(beta) variation in beluga (Delphinapterus leucas) and DQ(beta) variation in north atlantic right whales (Eubalaena glacialis).
300 $a 164 p.
500 $a Source: Dissertation Abstracts International, Volume: 59-08, Section: B, page: 3870.
500 $a Adviser: B. N. White.
502 $a Thesis (Ph.D.)--McMaster University (Canada), 1997.
520 $a Allelic variation at the Major Histocompatibility Complex (Mhc) class II loci $ and $ was assessed in a large sample ( $\ sim $3 00) of beluga (Delphinapterus leucas) and a sample ( $\ sim $1 2) of narwhal (Monodon monaceros). Mhc class II $ allelic variation was also analysed in a preliminary survey of right (Eubalaena glacialis) and bowhead (Balaena mysticetus) whales. In each survey variation was assessed by analysis of class II loci $\ beta $ chain exon 2 nucleotide sequences. Exon 2 encodes the peptide binding region of the class II molecules.
520 $a A low amount of variation was observed at the beluga $ locus while a low to moderate amount of variation was observed at the beluga $ locus and the right whale $ loci when compared with terrestrial mammals. Two $ loci in beluga and two $ loci in right and bowhead whales were detected. Comparison among beluga $, among beluga $1 , and among right whale $ sequences show, at each locus, a high ratio of nonsynonymous to synonymous substitutions per site. Further, in each case, the majority of substitutions did not maintain the physio-chemical properties of the residue and were found at sites implicated as being important in the selective binding of foreign antigen. Comparison of beluga and right whale $ sequences shows a reduced rate of synonymous substitutions in cetaceans.
520 $a No significant differences in Mhc allelic or genotypic frequencies were observed among beluga summering populations which are believed to share a common overwintering area in either the Hudson Strait or the Bering Sea. Significant differences were found among sampling locations of the High Arctic/Baffin Bay beluga population. $1 allele and genotype frequencies were also significantly different among the overwintering locations, Hudson Strait, Bering Sea, Baffin Bay, Cunningham Inlet, and the St. Lawrence. $ allele frequencies were only significantly different between the High Arctic/Baffin Bay beluga and all other sampling locations.
520 $a Comparison of $ and $1 allele and genotype frequencies within the St. Lawrence population between dead beached beluga and live biopsy darted whales shows no evidence of a sample collection bias. The effects of the historic bottleneck are observed upon examination of $1 - $ haplotypes. Evidence for linkage disequilibrium between these loci is noted in the St. Lawrence. Comparison of possible haplotypes shows the St. Lawrence has about half the haplotypes found in Arctic populations. (Abstract shortened by UMI.)
590 $a School code: 0197.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Zoology. $3 1018632
690 $a 0369
690 $a 0472
710 2 0 $a McMaster University (Canada). $3 1024893
773 0 $t Dissertation Abstracts International $g 59-08B.
790 1 0 $a White, B. N., $e advisor
790 $a 0197
791 $a Ph.D.
792 $a 1997
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ30162