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EFFECTS OF THE ANTICONVULSANT DRUGS ...

BUNCH, SUSAN ELIZABETH.

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EFFECTS OF THE ANTICONVULSANT DRUGS PHENYTOIN AND PRIMIDONE ON THE CANINE LIVER.

Record Type:	Electronic resources : Monograph/item
Title/Author:	EFFECTS OF THE ANTICONVULSANT DRUGS PHENYTOIN AND PRIMIDONE ON THE CANINE LIVER./
Author:	BUNCH, SUSAN ELIZABETH.
Description:	230 p.
Notes:	Source: Dissertation Abstracts International, Volume: 43-12, Section: B, page: 3874.
Contained By:	Dissertation Abstracts International43-12B.
Subject:	Biology, Veterinary Science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8309464

EFFECTS OF THE ANTICONVULSANT DRUGS PHENYTOIN AND PRIMIDONE ON THE CANINE LIVER.
BUNCH, SUSAN ELIZABETH.

EFFECTS OF THE ANTICONVULSANT DRUGS PHENYTOIN AND PRIMIDONE ON THE CANINE LIVER. - 230 p.

Source: Dissertation Abstracts International, Volume: 43-12, Section: B, page: 3874.

Thesis (Ph.D.)--Cornell University, 1983.

Adverse reactions to therapeutic agents in dogs are unusual. References to the hepatotoxicity of anticonvulsant drugs have been made in textbooks of veterinary gastroenterology, but only two reports of apparent acute toxicity in dogs have been published. The purpose of the research described in this thesis was to test the hypothesis that anticonvulsant drugs are, under certain circumstances, hepatotoxic in the dog.Subjects--Topical Terms:

1021733
Biology, Veterinary Science.

EFFECTS OF THE ANTICONVULSANT DRUGS PHENYTOIN AND PRIMIDONE ON THE CANINE LIVER.
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035 $a (UnM)AAI8309464
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100 1 $a BUNCH, SUSAN ELIZABETH. $3 1927838
245 1 0 $a EFFECTS OF THE ANTICONVULSANT DRUGS PHENYTOIN AND PRIMIDONE ON THE CANINE LIVER.
300 $a 230 p.
500 $a Source: Dissertation Abstracts International, Volume: 43-12, Section: B, page: 3874.
502 $a Thesis (Ph.D.)--Cornell University, 1983.
520 $a Adverse reactions to therapeutic agents in dogs are unusual. References to the hepatotoxicity of anticonvulsant drugs have been made in textbooks of veterinary gastroenterology, but only two reports of apparent acute toxicity in dogs have been published. The purpose of the research described in this thesis was to test the hypothesis that anticonvulsant drugs are, under certain circumstances, hepatotoxic in the dog.
520 $a Severe, chronic liver disease was observed in 5 dogs examined at the New York State College of Veterinary Medicine that had been treated for 2-3 years with anticonvulsant drugs. Hepatic cirrhosis was documented by histologic examination in 4 of the 5 dogs. This represented 31% of all cases of cirrhosis observed during the same time span and suggested an association between chronic liver disease and extended anticonvulsant drug therapy.
520 $a Liver function was evaluated in 46 canine seizure patients that had been given anticonvulsant drugs for 6 months or longer by serum biochemical analysis and sulphobromophthalein excretion. Two dogs were clinically ill at the time of examination and subsequently died of hepatic failure. Four of the remaining 44 clinically healthy dogs (9%) had hepatic function profiles that suggested serious hepatic insufficiency.
520 $a Experimental studies of the effects of long-term administration to dogs of primidone, phenytoin, or both drugs in combination given at conventional and three times the conventional dosages were conducted for 6 months. Sequential evaluations of liver function and morphology were performed during this time. The most pronounced serum biochemical abnormalities (increased activities of ALT, AP, GGT, and low concentrations of albumin and cholesterol) were observed in dogs given primidone alone or in combination with phenytoin at high dosages. Ultrastructural studies of the liver showed that the most severe morphologic changes were observed in dogs given both drugs in combination. Three dogs given both drugs became clinically ill after 2-3 months of treatment, and necropsy revealed intrahepatic cholestasis.
520 $a The results of these studies indicate that serious hepatic injury may be associated with anticonvulsant drug therapy. The mechanism of this apparently idiosyncratic reaction is not known, but may involve direct hepatic injury in selected individuals or a co-factor such as an environmental toxin.
590 $a School code: 0058.
650 4 $a Biology, Veterinary Science. $3 1021733
690 $a 0778
710 2 0 $a Cornell University. $3 530586
773 0 $t Dissertation Abstracts International $g 43-12B.
790 $a 0058
791 $a Ph.D.
792 $a 1983
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8309464