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Nitrogen and oxygen radicals in isch...

Dobrucki, Wawrzyniec Lawrence.

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Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain./
Author:	Dobrucki, Wawrzyniec Lawrence.
Description:	158 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2164.
Contained By:	Dissertation Abstracts International64-05B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3089485
ISBN:	0496372171

Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain.
Dobrucki, Wawrzyniec Lawrence.

Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain. - 158 p.

Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2164.

Thesis (Ph.D.)--Ohio University, 2003.

The purpose of this work was to examine the role played by a deficit in nitric oxide (NO) and overproduction of superoxide ( O-2 ) and peroxynitrite (ONOO-) in contributing to the large cerebral infarcts seen in hypertensive and/or old animals. The role of NO-mediated mechanism in hypobaric hypoxia has been also studied. Additionally, the positive effect of the hypoxic adaptation on cerebral ischemia and reperfusion (I/R) has been demonstrated.

ISBN: 0496372171Subjects--Topical Terms:

586156
Chemistry, Analytical.

Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain.
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020 $a 0496372171
035 $a (UnM)AAI3089485
035 $a AAI3089485
040 $a UnM $c UnM
100 1 $a Dobrucki, Wawrzyniec Lawrence. $3 1925622
245 1 0 $a Nitrogen and oxygen radicals in ischemic and hypoxic injury of the brain.
300 $a 158 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2164.
500 $a Director: Tadeusz Malinski.
502 $a Thesis (Ph.D.)--Ohio University, 2003.
520 $a The purpose of this work was to examine the role played by a deficit in nitric oxide (NO) and overproduction of superoxide ( O-2 ) and peroxynitrite (ONOO-) in contributing to the large cerebral infarcts seen in hypertensive and/or old animals. The role of NO-mediated mechanism in hypobaric hypoxia has been also studied. Additionally, the positive effect of the hypoxic adaptation on cerebral ischemia and reperfusion (I/R) has been demonstrated.
520 $a Cerebral infarction was produced in rats by occlusion of the middle cerebral artery followed by reperfusion. Studies were performed in animals of different age, genotype (spontaneously hypertensive stroke-prone), animals subjected to NO synthase blockade, and animals subjected to hypobaric hypoxia followed by adaptation process (30 days at 5,000 m above sea level).
520 $a NO and O-2 released in the brain were monitored using a set of specially designed microsensors with a 1 nM detection limit for both NO and O-2 .
520 $a The direct relationships between: ONOO- concentration and infarct size, age and infarct size, and between altitude and both NO and O-2 concentrations released from the brain, have been established. Moreover, new evidence has been presented that neuroprotective properties of adaptation to hypoxia are solely due to an increase in bioactive NO.
590 $a School code: 0167.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0486
690 $a 0317
690 $a 0760
710 2 0 $a Ohio University. $3 626637
773 0 $t Dissertation Abstracts International $g 64-05B.
790 1 0 $a Malinski, Tadeusz, $e advisor
790 $a 0167
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3089485