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Effects of high salt intake on endot...

Bratcher, Adrienne Patrece.

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Effects of high salt intake on endothelial-mediated dilation and construction in the vasculature.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of high salt intake on endothelial-mediated dilation and construction in the vasculature./
Author:	Bratcher, Adrienne Patrece.
Description:	110 p.
Notes:	Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2868.
Contained By:	Dissertation Abstracts International68-05B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3267076
ISBN:	9780549051589

Effects of high salt intake on endothelial-mediated dilation and construction in the vasculature.
Bratcher, Adrienne Patrece.

Effects of high salt intake on endothelial-mediated dilation and construction in the vasculature. - 110 p.

Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2868.

Thesis (Ph.D.)--University of Louisville, 2007.

Hypertension is a major health problem in the United States, where more than 50 million people (1 in 4 adults) have the condition. Hypertension is commonly associated with a narrowing of the arteries, which causes high blood pressure. High dietary salt intake has been shown to contribute to the development of hypertension in the DOCA-salt model. However, elevations in salt intake alone may cause significant changes in the microvessel response to vasoactive drugs. Therefore, this dissertation is focused on the determination that increased dietary salt intake alone will have a major effect on the sensitivity of microvessels/macrovessels exposed to various vasoactive agents. Our data suggest that the dilator and contrictor responses in the microvasculature are decreased. However, there appears to only be an increase in constrictor response and similar decrease in dilator response in the macrovasculature. Thus, impairment of the arteriolar and aortic responses due to increased dietary conditions could predispose rats to the development of hypertension. Our data also demonstrate that these alterations could be due to an increase in oxidative stress.

ISBN: 9780549051589Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Effects of high salt intake on endothelial-mediated dilation and construction in the vasculature.
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100 1 $a Bratcher, Adrienne Patrece. $3 1924336
245 1 0 $a Effects of high salt intake on endothelial-mediated dilation and construction in the vasculature.
300 $a 110 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2868.
500 $a Adviser: Irving G. Joshua.
502 $a Thesis (Ph.D.)--University of Louisville, 2007.
520 $a Hypertension is a major health problem in the United States, where more than 50 million people (1 in 4 adults) have the condition. Hypertension is commonly associated with a narrowing of the arteries, which causes high blood pressure. High dietary salt intake has been shown to contribute to the development of hypertension in the DOCA-salt model. However, elevations in salt intake alone may cause significant changes in the microvessel response to vasoactive drugs. Therefore, this dissertation is focused on the determination that increased dietary salt intake alone will have a major effect on the sensitivity of microvessels/macrovessels exposed to various vasoactive agents. Our data suggest that the dilator and contrictor responses in the microvasculature are decreased. However, there appears to only be an increase in constrictor response and similar decrease in dilator response in the macrovasculature. Thus, impairment of the arteriolar and aortic responses due to increased dietary conditions could predispose rats to the development of hypertension. Our data also demonstrate that these alterations could be due to an increase in oxidative stress.
590 $a School code: 0110.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Biology, Physiology. $3 1017816
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710 2 0 $a University of Louisville. $3 1017614
773 0 $t Dissertation Abstracts International $g 68-05B.
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3267076