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Fabrication and evaluation of ciprof...

Arnold, Matthew.

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Fabrication and evaluation of ciprofloxacin-loaded PLGA microparticles as aerosols for deep lung deposition.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Fabrication and evaluation of ciprofloxacin-loaded PLGA microparticles as aerosols for deep lung deposition./
Author:	Arnold, Matthew.
Description:	104 p.
Notes:	Source: Masters Abstracts International, Volume: 45-03, page: 1561.
Contained By:	Masters Abstracts International45-03.
Subject:	Engineering, Chemical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1440550

Fabrication and evaluation of ciprofloxacin-loaded PLGA microparticles as aerosols for deep lung deposition.
Arnold, Matthew.

Fabrication and evaluation of ciprofloxacin-loaded PLGA microparticles as aerosols for deep lung deposition. - 104 p.

Source: Masters Abstracts International, Volume: 45-03, page: 1561.

Thesis (M.S.)--University of Kansas, 2007.

Whether treating the lung locally or using it as a gateway for systemic delivery of large molecular weight drugs, a common goal is to deliver drug to the deep lung. Researchers have repeatedly reported that a particle size of &sim;1-3 microm in aerodynamic diameter will efficiently bypass the filtering system of the mouth and upper airway. Also, large porous particles exhibiting the desired aerodynamic diameter but having increased (>20 microm) geometric diameter can potentially reduce particle aggregation and avoid phagocytotic clearance by alveolar macrophages. In this paper, the feasibility of fabricating porous polymeric particles for aerosol drug delivery is investigated, utilizing a particle fabrication technology that allows a high degree of control over the particle size and distributions, resulting in 95% of the particles within 0.5% of the target diameter. Drug-laden porous particles loaded with the general antibiotic ciprofloxacin were fabricated in sizes ranging from 5 to 26 microns geometric diameter, and with a reduced specific gravity that resulted in a lower aerodynamic diameter. These particles typically had encapsulation efficiencies of 1 to 9 percent. An in vitro release study was performed on both porous and solid particles. Typically, the smaller particles, whether solid or porous, released at a faster rate than larger ones, and for those particles of similar sizes, the porous particles released more rapidly than the solid ones. The 5 micron porous particles released &sim;75% of the encapsulated drug within 5 days, whereas it took almost 20 days for the 27 micron porous particles to reach 75%. Likewise, the 5 micron solid particles took almost 10 days to release 75% of their drug. Finally, the factors controlling porosity and drug loading are discussed, along with a mathematical model to more fully understand what is happening during particle formation.Subjects--Topical Terms:

1018531
Engineering, Chemical.

Fabrication and evaluation of ciprofloxacin-loaded PLGA microparticles as aerosols for deep lung deposition.
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100 1 $a Arnold, Matthew. $3 1923305
245 1 0 $a Fabrication and evaluation of ciprofloxacin-loaded PLGA microparticles as aerosols for deep lung deposition.
300 $a 104 p.
500 $a Source: Masters Abstracts International, Volume: 45-03, page: 1561.
500 $a Adviser: Cory Berkland.
502 $a Thesis (M.S.)--University of Kansas, 2007.
520 $a Whether treating the lung locally or using it as a gateway for systemic delivery of large molecular weight drugs, a common goal is to deliver drug to the deep lung. Researchers have repeatedly reported that a particle size of &sim;1-3 microm in aerodynamic diameter will efficiently bypass the filtering system of the mouth and upper airway. Also, large porous particles exhibiting the desired aerodynamic diameter but having increased (>20 microm) geometric diameter can potentially reduce particle aggregation and avoid phagocytotic clearance by alveolar macrophages. In this paper, the feasibility of fabricating porous polymeric particles for aerosol drug delivery is investigated, utilizing a particle fabrication technology that allows a high degree of control over the particle size and distributions, resulting in 95% of the particles within 0.5% of the target diameter. Drug-laden porous particles loaded with the general antibiotic ciprofloxacin were fabricated in sizes ranging from 5 to 26 microns geometric diameter, and with a reduced specific gravity that resulted in a lower aerodynamic diameter. These particles typically had encapsulation efficiencies of 1 to 9 percent. An in vitro release study was performed on both porous and solid particles. Typically, the smaller particles, whether solid or porous, released at a faster rate than larger ones, and for those particles of similar sizes, the porous particles released more rapidly than the solid ones. The 5 micron porous particles released &sim;75% of the encapsulated drug within 5 days, whereas it took almost 20 days for the 27 micron porous particles to reach 75%. Likewise, the 5 micron solid particles took almost 10 days to release 75% of their drug. Finally, the factors controlling porosity and drug loading are discussed, along with a mathematical model to more fully understand what is happening during particle formation.
590 $a School code: 0099.
650 4 $a Engineering, Chemical. $3 1018531
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0542
690 $a 0572
710 2 0 $a University of Kansas. $3 626626
773 0 $t Masters Abstracts International $g 45-03.
790 1 0 $a Berkland, Cory, $e advisor
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791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1440550