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The effect of increased mechanical l...

Curwin, Sandra Lynn.

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The effect of increased mechanical load on growing tendon.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effect of increased mechanical load on growing tendon./
Author:	Curwin, Sandra Lynn.
Description:	107 p.
Notes:	Source: Dissertation Abstracts International, Volume: 49-09, Section: B, page: 3732.
Contained By:	Dissertation Abstracts International49-09B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8824655

The effect of increased mechanical load on growing tendon.
Curwin, Sandra Lynn.

The effect of increased mechanical load on growing tendon. - 107 p.

Source: Dissertation Abstracts International, Volume: 49-09, Section: B, page: 3732.

Thesis (Ph.D.)--University of California, Los Angeles, 1988.

The right medial gastrocnemius muscle and tendon were removed from 70 White-Leghorn roosters to induce a compensatory hypertrophy of the lateral gastrocnemius muscle, thus increasing the mechanical load on the lateral gastrocnemius tendon. At 2, 4, and 8 weeks after surgery, tendons were removed and divided into proximal, middle, and distal regions, allowing the effects of age, region and increased load to be examined. Regional variations were observed in hydroxyproline (Hyp) concentration (lower in distal region in 4-week and 8-week groups), hydroxypyridinium (OHP) crosslinks (higher in distal region of 2-week and 8-week groups) and galactosamine (higher in middle and distal regions of 8-week group). Age-related changes included increases in tendon weight, tendon length, collagen and crosslink concentration, and increase in collagen fibril diameter, while hexuronate (HEX) glucosamine (GlcN), galactosamine (GalN), collagen turnover and number of fibrils per square micron decreased with age. Increased loading resulted in increased tendon weight/length ratio, increased OHP crosslinks, increased net deposition of newly synthesized collagen, increased GlcN concentration, and increased collagen fibril diameters after 8 weeks of hypertrophy, while collagen concentration decreased at all time points. An increase in small diameter fibrils was observed at 2 weeks, this shifted toward larger diameter fibrils at 4 and 8 weeks. No change in the amount of type III collagen was observed at 2 and 8 weeks, but type III collagen was increased in the middle and distal regions of the experimental limbs of the 8-week animals. These data suggest that increased mechanical loading of growing tendon results in an increased in collagen and ground substance production and causes increased crosslinking and enlargement of collagen fibrils.Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The effect of increased mechanical load on growing tendon.
LDR:02719nmm 2200277 4500 001 1832488
005 20070813115758.5
008 130610s1988 eng d
035 $a (UMI)AAI8824655
035 $a AAI8824655
040 $a UMI $c UMI
100 1 $a Curwin, Sandra Lynn. $3 1921214
245 1 4 $a The effect of increased mechanical load on growing tendon.
300 $a 107 p.
500 $a Source: Dissertation Abstracts International, Volume: 49-09, Section: B, page: 3732.
500 $a Chair: Arthur C. Valias.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 1988.
520 $a The right medial gastrocnemius muscle and tendon were removed from 70 White-Leghorn roosters to induce a compensatory hypertrophy of the lateral gastrocnemius muscle, thus increasing the mechanical load on the lateral gastrocnemius tendon. At 2, 4, and 8 weeks after surgery, tendons were removed and divided into proximal, middle, and distal regions, allowing the effects of age, region and increased load to be examined. Regional variations were observed in hydroxyproline (Hyp) concentration (lower in distal region in 4-week and 8-week groups), hydroxypyridinium (OHP) crosslinks (higher in distal region of 2-week and 8-week groups) and galactosamine (higher in middle and distal regions of 8-week group). Age-related changes included increases in tendon weight, tendon length, collagen and crosslink concentration, and increase in collagen fibril diameter, while hexuronate (HEX) glucosamine (GlcN), galactosamine (GalN), collagen turnover and number of fibrils per square micron decreased with age. Increased loading resulted in increased tendon weight/length ratio, increased OHP crosslinks, increased net deposition of newly synthesized collagen, increased GlcN concentration, and increased collagen fibril diameters after 8 weeks of hypertrophy, while collagen concentration decreased at all time points. An increase in small diameter fibrils was observed at 2 weeks, this shifted toward larger diameter fibrils at 4 and 8 weeks. No change in the amount of type III collagen was observed at 2 and 8 weeks, but type III collagen was increased in the middle and distal regions of the experimental limbs of the 8-week animals. These data suggest that increased mechanical loading of growing tendon results in an increased in collagen and ground substance production and causes increased crosslinking and enlargement of collagen fibrils.
590 $a School code: 0031.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
690 $a 0433
690 $a 0487
690 $a 0564
710 2 0 $a University of California, Los Angeles. $3 626622
773 0 $t Dissertation Abstracts International $g 49-09B.
790 1 0 $a Valias, Arthur C., $e advisor
790 $a 0031
791 $a Ph.D.
792 $a 1988
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8824655