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In-vivo methodologies of carbon-13 N...

Yahya, Atiyah.

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In-vivo methodologies of carbon-13 NMR spectroscopy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	In-vivo methodologies of carbon-13 NMR spectroscopy./
Author:	Yahya, Atiyah.
Description:	174 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 2109.
Contained By:	Dissertation Abstracts International67-04B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR14066
ISBN:	9780494140666

In-vivo methodologies of carbon-13 NMR spectroscopy.
Yahya, Atiyah.

In-vivo methodologies of carbon-13 NMR spectroscopy. - 174 p.

Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 2109.

Thesis (Ph.D.)--University of Alberta (Canada), 2006.

The work conducted in this thesis is the first part of a research programme to develop the tools and procedures to introduce dynamic measurements of neurotransmitter metabolism into collaborative projects with psychiatrists and neurologists on patients with brain disorders or diseases. Carbon-13, 13C, magnetic resonance spectroscopy (MRS) is a valuable tool in the determination of metabolic flux rates. Because 13C is only 1.1% naturally abundant, infusing 13C labelled substrates into a subject allows the time courses of 13C label incorporation into metabolic products such as neurotransmitter glutamate, and hence a key metabolic flux rate to be measured. Carbon-13 is challenging to measure directly, and therefore methodologies that involve both the 13C and 1H nuclei, known as double resonance techniques, are employed to enhance specificity and sensitivity. Such techniques exploit the heteronuclear scalar coupling that exists between 13C nuclei and the bonded 1H nuclei to take advantage of the higher sensitivity of 1H spins.

ISBN: 9780494140666Subjects--Topical Terms:

586156
Chemistry, Analytical.

In-vivo methodologies of carbon-13 NMR spectroscopy.
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245 1 0 $a In-vivo methodologies of carbon-13 NMR spectroscopy.
300 $a 174 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 2109.
502 $a Thesis (Ph.D.)--University of Alberta (Canada), 2006.
520 $a The work conducted in this thesis is the first part of a research programme to develop the tools and procedures to introduce dynamic measurements of neurotransmitter metabolism into collaborative projects with psychiatrists and neurologists on patients with brain disorders or diseases. Carbon-13, 13C, magnetic resonance spectroscopy (MRS) is a valuable tool in the determination of metabolic flux rates. Because 13C is only 1.1% naturally abundant, infusing 13C labelled substrates into a subject allows the time courses of 13C label incorporation into metabolic products such as neurotransmitter glutamate, and hence a key metabolic flux rate to be measured. Carbon-13 is challenging to measure directly, and therefore methodologies that involve both the 13C and 1H nuclei, known as double resonance techniques, are employed to enhance specificity and sensitivity. Such techniques exploit the heteronuclear scalar coupling that exists between 13C nuclei and the bonded 1H nuclei to take advantage of the higher sensitivity of 1H spins.
520 $a The objectives of this thesis were to enhance the volume range, sensitivity and specificity of dynamic 13C measurements. The first two were addressed by the design, construction, and testing of a dual-tuned open radiofrequency coil. The advantage of this coil is that as a single-unit it provides uniform radiofrequency fields at both 13C and 1H frequencies over a larger territory of brain than the coil commonly used in 13C studies. The final, and most substantial objective (specificity) involved the incorporation of homonuclear 1H coupling as well as heteronuclear (1H- 13C) coupling in the NMR model. Homonuclear 1H coupling has been uniformly neglected in the literature. The result of its inclusion, demonstrated both theoretically and experimentally, was that it can lead to quantification errors of the order of several tens of percent and in some cases to less than optimal sequence design. The inclusion of 1H homonuclear coupling was evaluated in a number of direct (three in all) and indirect (two in all) techniques for measuring 13C spectra from a localized volume.
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