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Mechanical behavior of human stratum...

Wu, Kenneth Shih-heng.

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Mechanical behavior of human stratum corneum: Relationship to tissue structure and condition.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanical behavior of human stratum corneum: Relationship to tissue structure and condition./
Author:	Wu, Kenneth Shih-heng.
Description:	165 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2803.
Contained By:	Dissertation Abstracts International67-05B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3219412
ISBN:	9780542708541

Mechanical behavior of human stratum corneum: Relationship to tissue structure and condition.
Wu, Kenneth Shih-heng.

Mechanical behavior of human stratum corneum: Relationship to tissue structure and condition. - 165 p.

Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2803.

Thesis (Ph.D.)--Stanford University, 2006.

The outermost layer of skin, the stratum corneum (SC), provides mechanical protection and a controlled barrier to the external environment while subject to highly variable conditions including natural changes in local temperature and humidity as well as potentially damaging acute and chronic chemical exposure. Tissue integrity is central to SC protective properties, and such exposure can be deleterious to SC structure and mechanical properties. Mechanics-based techniques to study both in-plane and out-of-plane mechanical behavior of human SC tissue as a function of temperature, hydration, and chemical treatment are presented.

ISBN: 9780542708541Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Mechanical behavior of human stratum corneum: Relationship to tissue structure and condition.
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100 1 $a Wu, Kenneth Shih-heng. $3 1920544
245 1 0 $a Mechanical behavior of human stratum corneum: Relationship to tissue structure and condition.
300 $a 165 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2803.
500 $a Adviser: Reinhold H. Dauskardt.
502 $a Thesis (Ph.D.)--Stanford University, 2006.
520 $a The outermost layer of skin, the stratum corneum (SC), provides mechanical protection and a controlled barrier to the external environment while subject to highly variable conditions including natural changes in local temperature and humidity as well as potentially damaging acute and chronic chemical exposure. Tissue integrity is central to SC protective properties, and such exposure can be deleterious to SC structure and mechanical properties. Mechanics-based techniques to study both in-plane and out-of-plane mechanical behavior of human SC tissue as a function of temperature, hydration, and chemical treatment are presented.
520 $a The in-plane viscoelastic properties of SC were examined to provide a more detailed understanding of underlying time-dependent processes. Creep recovery experiments were employed to probe retardation time scales. Stretched exponential and computational analyses of SC responses provided a measure of the distribution of time scales and their dependence on conditioning and loading parameters. Retardation times were found to decrease with increasing hydration, likely linked to keratin-keratin interactions, and the distribution of process time scales was found to sharpen correspondingly.
520 $a Mechanical and fracture behavior of SC in the out-of-plane direction is examined as well. Delamination energy values were quantified for SC for the first time in this work, and values were found to range from &sim;1--8 J/m2, typically decreasing with increasing hydration and temperature. Removal of intercellular lipids significantly elevated values at each condition with the range &sim;4--13 J/m2. The SC possesses gradients through its thickness, and examination of the delamination properties through the thickness of the SC yielded increasing values with depth into the SC ranging from &sim;3--15 J/m2 as might be expected given the natural degradation of protein linkages, or corneosomes, toward the outer skin surface. SC also was shown to be subject to time-dependent, or subcritical, delamination failure that accelerates with increased hydration providing design guidelines for development of technologies that interface with the skin.
590 $a School code: 0212.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Biophysics, General. $3 1019105
650 4 $a Engineering, Materials Science. $3 1017759
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710 2 0 $a Stanford University. $3 754827
773 0 $t Dissertation Abstracts International $g 67-05B.
790 1 0 $a Dauskardt, Reinhold H., $e advisor
790 $a 0212
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3219412