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Peptide fragmentation and amino acid...

Zhang, Qingfen.

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Peptide fragmentation and amino acid quantification by mass spectrometry.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Peptide fragmentation and amino acid quantification by mass spectrometry./
作者:	Zhang, Qingfen.
面頁冊數:	249 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0863.
Contained By:	Dissertation Abstracts International67-02B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3207651
ISBN:	9780542550089

Peptide fragmentation and amino acid quantification by mass spectrometry.
Zhang, Qingfen.

Peptide fragmentation and amino acid quantification by mass spectrometry. - 249 p.

Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0863.

Thesis (Ph.D.)--The University of Arizona, 2006.

Research presented in this dissertation falls into two parts: fragmentation mechanisms of peptide and fragmentation mechanism of amino acid derivatives. The study of peptide fragmentation may help to improve protein identification by incorporating the rules governing this process into search algorithms. This study elucidates the chemical 'rules' governing peptide dissociation. It is believed that these 'rules' can be incorporated into searching algorithms to achieve better protein identification. The present study focuses on the effects of different amino acids on fragmentation. Amino acids with a wide range of different chemical and physical properties are investigated, including amino acids with hydrophilic side chains, amino acids with aliphatic side chains and alpha, beta, and gamma-amino acids without side chains. It can be concluded from the present studies that the different amino acid properties have great influence on the peptide fragmentation and spectrum appearance.

ISBN: 9780542550089Subjects--Topical Terms:

586156
Chemistry, Analytical.

Peptide fragmentation and amino acid quantification by mass spectrometry.
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502 $a Thesis (Ph.D.)--The University of Arizona, 2006.
520 $a Research presented in this dissertation falls into two parts: fragmentation mechanisms of peptide and fragmentation mechanism of amino acid derivatives. The study of peptide fragmentation may help to improve protein identification by incorporating the rules governing this process into search algorithms. This study elucidates the chemical 'rules' governing peptide dissociation. It is believed that these 'rules' can be incorporated into searching algorithms to achieve better protein identification. The present study focuses on the effects of different amino acids on fragmentation. Amino acids with a wide range of different chemical and physical properties are investigated, including amino acids with hydrophilic side chains, amino acids with aliphatic side chains and alpha, beta, and gamma-amino acids without side chains. It can be concluded from the present studies that the different amino acid properties have great influence on the peptide fragmentation and spectrum appearance.
520 $a The study of fragmentation mechanisms of amino acid derivatives is another focus of this dissertation. Based on the fragmentation mechanism study, a quantification method was developed. The method can distinguish glutamine with 15N-label at N-terminal amine vs. the side chain even if they have same molecular weight. Ammonia metabolism was successfully monitored by feeding mosquitoes with isotope-labeled compounds and subsequently measuring the amount of the labeled amino acids. This method demonstrates the power of mass spectrometry in metabolism studies.
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