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Colon specific delivery using ethylc...

Yelamanchili, Satish.

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Colon specific delivery using ethylcellulose and chitosan in a compression coated tablet.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Colon specific delivery using ethylcellulose and chitosan in a compression coated tablet./
Author:	Yelamanchili, Satish.
Description:	88 p.
Notes:	Source: Masters Abstracts International, Volume: 45-01, page: 0298.
Contained By:	Masters Abstracts International45-01.
Subject:	Health Sciences, Pharmacy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1438060
ISBN:	9780542889653

Colon specific delivery using ethylcellulose and chitosan in a compression coated tablet.
Yelamanchili, Satish.

Colon specific delivery using ethylcellulose and chitosan in a compression coated tablet. - 88 p.

Source: Masters Abstracts International, Volume: 45-01, page: 0298.

Thesis (M.S.)--University of Missouri - Kansas City, 2006.

Ethylcellulose and chitosan are used for colon specific delivery in a compression coated tablet prepared by direct compression method. Three types of chitosan are used and three levels of chitosan are studied. Caffeine was used as a model drug in this study. The influence of chitosan type and level on the hardness, friability and drug release were studied. There was no influence of the type of chitosan and level of chitosan on hardness and friability. Drug release occurred primarily due to the opening of the coat, with subsequent drug dissolution and diffusion from the core tablet. Chitosan types have no effect on the release in simulated intestinal fluid, while the level of chitosan modified the release. The chitosan level also influenced the release in presence of rat cecal and colonic enzymes. An enteric coat is needed to protect the tablet from the gastric environment.

ISBN: 9780542889653Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Colon specific delivery using ethylcellulose and chitosan in a compression coated tablet.
LDR:01752nmm 2200265 4500 001 1831086
005 20070507072933.5
008 130610s2006 eng d
020 $a 9780542889653
035 $a (UnM)AAI1438060
035 $a AAI1438060
040 $a UnM $c UnM
100 1 $a Yelamanchili, Satish. $3 1919898
245 1 0 $a Colon specific delivery using ethylcellulose and chitosan in a compression coated tablet.
300 $a 88 p.
500 $a Source: Masters Abstracts International, Volume: 45-01, page: 0298.
500 $a Adviser: Steven H. Neau.
502 $a Thesis (M.S.)--University of Missouri - Kansas City, 2006.
520 $a Ethylcellulose and chitosan are used for colon specific delivery in a compression coated tablet prepared by direct compression method. Three types of chitosan are used and three levels of chitosan are studied. Caffeine was used as a model drug in this study. The influence of chitosan type and level on the hardness, friability and drug release were studied. There was no influence of the type of chitosan and level of chitosan on hardness and friability. Drug release occurred primarily due to the opening of the coat, with subsequent drug dissolution and diffusion from the core tablet. Chitosan types have no effect on the release in simulated intestinal fluid, while the level of chitosan modified the release. The chitosan level also influenced the release in presence of rat cecal and colonic enzymes. An enteric coat is needed to protect the tablet from the gastric environment.
590 $a School code: 0134.
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0572
710 2 0 $a University of Missouri - Kansas City. $3 1021712
773 0 $t Masters Abstracts International $g 45-01.
790 1 0 $a Neau, Steven H., $e advisor
790 $a 0134
791 $a M.S.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1438060