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Interaction of tetracycline and fluo...

Gu, Cheng.

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Interaction of tetracycline and fluoroquinolone antibiotics with environmental particles.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Interaction of tetracycline and fluoroquinolone antibiotics with environmental particles./
作者:	Gu, Cheng.
面頁冊數:	124 p.
附註:	Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3370.
Contained By:	Dissertation Abstracts International67-06B.
標題:	Agriculture, Soil Science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222795
ISBN:	9780542752964

Interaction of tetracycline and fluoroquinolone antibiotics with environmental particles.
Gu, Cheng.

Interaction of tetracycline and fluoroquinolone antibiotics with environmental particles. - 124 p.

Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3370.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.

The major goal of this study was to determine the effect of solution chemistry variables on the sorption of commonly used antibiotics to environmental particles. Interaction of selected antibiotics, ciprofloxacin and tetracycline, with the hydrous oxides of Al (HAO) and Fe (HFO), soil humic acid, and humic-hydrous Al oxide complexes was investigated. A combination of macroscopic batch, quantitative modeling, and spectroscopic techniques were employed to determine the dominant interactions for the above systems.

ISBN: 9780542752964Subjects--Topical Terms:

1017824
Agriculture, Soil Science.

Interaction of tetracycline and fluoroquinolone antibiotics with environmental particles.
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245 1 0 $a Interaction of tetracycline and fluoroquinolone antibiotics with environmental particles.
300 $a 124 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3370.
500 $a Adviser: K. G. Karthikeyan.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.
520 $a The major goal of this study was to determine the effect of solution chemistry variables on the sorption of commonly used antibiotics to environmental particles. Interaction of selected antibiotics, ciprofloxacin and tetracycline, with the hydrous oxides of Al (HAO) and Fe (HFO), soil humic acid, and humic-hydrous Al oxide complexes was investigated. A combination of macroscopic batch, quantitative modeling, and spectroscopic techniques were employed to determine the dominant interactions for the above systems.
520 $a Both tetracycline and ciprofloxacin formed strong complexes on the surface of HAO and HFO, and ligand (antibiotic)-promoted dissolution of both the hydrous oxides was observed. The surface interactions appeared to occur primarily on the edge Al/Fe atoms of the minerals, which are the sites with singly-coordinated surface hydroxyl groups and are often considered as active sorption sites. Due to the similarity in sorption trends for both these antibiotics with HAO and HFO, subsequent experiments with humic substances (HS) and humic-HAO complexes were performed only on tetracycline. The interaction of tetracycline with a model HS (Elliott Soil Humic Acid, ESHA) showed a strong pH and ionic strength (I) dependence. Cation exchange was proposed as the major mechanism for tetracycline complexation with ESHA. The presence of a divalent metal cation (Ca2+) increased tetracycline sorption suggesting that ternary complex formation (cation bridging) could be important, especially at higher bridging ion concentrations. Aggregation of ESHA was observed in the presence of tetracycline, which could result in different microscopic pathways during sorption and desorption steps leading to an apparent hysteretic behavior. Strong affinities for HS exhibited by HAO resulted in a significant decrease in the sorption of tetracycline to HAO in the presence of ESHA. HS could influence tetracycline sorption by directly competing for potential sorption sites and/or by altering the surface charge properties of inorganic minerals.
520 $a The results from this study indicate that soil components can strongly influence the fate, transformation and reactivity of antibiotics in subsurface environments. This research work provides a better understanding of the sorption processes and should help in evaluating the ability of soils to act as a potential "sinks" for antibiotic compounds.
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