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Modeling and simulation of lab-on-a-...

Wang, Yi.

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Modeling and simulation of lab-on-a-chip systems.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Modeling and simulation of lab-on-a-chip systems./
Author:	Wang, Yi.
Description:	220 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5653.
Contained By:	Dissertation Abstracts International66-10B.
Subject:	Engineering, Mechanical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3191618
ISBN:	9780542363313

Modeling and simulation of lab-on-a-chip systems.
Wang, Yi.

Modeling and simulation of lab-on-a-chip systems. - 220 p.

Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5653.

Thesis (Ph.D.)--Carnegie Mellon University, 2005.

This thesis presents a behavioral modeling and schematic simulation methodology for top-down Lab-on-a-Chip (LoC) design. The methodology involves decomposing a complex LoC system into a small set of elements. Each of the elements is associated with a parameterized behavioral model that describes its electric and biofluidic behavior. Key issues addressed include schematic representation, behavioral multi-physics modeling and numerical and experimental validation.

ISBN: 9780542363313Subjects--Topical Terms:

783786
Engineering, Mechanical.

Modeling and simulation of lab-on-a-chip systems.
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100 1 $a Wang, Yi. $3 1035436
245 1 0 $a Modeling and simulation of lab-on-a-chip systems.
300 $a 220 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5653.
500 $a Adviser: Qiao Lin.
502 $a Thesis (Ph.D.)--Carnegie Mellon University, 2005.
520 $a This thesis presents a behavioral modeling and schematic simulation methodology for top-down Lab-on-a-Chip (LoC) design. The methodology involves decomposing a complex LoC system into a small set of elements. Each of the elements is associated with a parameterized behavioral model that describes its electric and biofluidic behavior. Key issues addressed include schematic representation, behavioral multi-physics modeling and numerical and experimental validation.
520 $a The modeling effort focuses on sample transport in LoC devices. Turn and Joule heating induced dispersion in electrophoretic separation chips are studied using the method of moments. The skew of the species band is effectively represented by a set of Fourier cosine series coefficients that are obtained analytically. These coefficients capture the effect of band skew on separation performance in various complex chip geometries (including multiple turns). Variations of sample concentration profiles in laminar diffusion-based micromixers are also derived using the Fourier cosine series representation. The model holds for arbitrary sample flow ratios and inlet concentration profiles, and accurately considers the overall effects of device topology, size and electric field on mixing performance. In addition, a simplified reaction model is developed and integrated with the separation and mixing models to perform system-level schematic simulations of an integrated LoC system. Simulation results at both element and system levels are validated by numerical and experimental data. Excellent accuracy (generally less than < 5% in relative error) and tremendous speedup (> 100 x) have been achieved when compared with finite element analysis. The mixing model is also adapted to pressure driven flow to propose and design a novel concentration gradient generator. The resulting modeling and simulation framework is a significant contribution to balancing the needs for efficiency and accuracy in biofluidic LoC design.
590 $a School code: 0041.
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0548
690 $a 0541
710 2 0 $a Carnegie Mellon University. $3 1018096
773 0 $t Dissertation Abstracts International $g 66-10B.
790 1 0 $a Lin, Qiao, $e advisor
790 $a 0041
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3191618