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Technetium and rhenium radiopharmace...

Lazarova, Neva.

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Technetium and rhenium radiopharmaceutical agents in nuclear medicine: Design and synthesis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Technetium and rhenium radiopharmaceutical agents in nuclear medicine: Design and synthesis./
Author:	Lazarova, Neva.
Description:	220 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5402.
Contained By:	Dissertation Abstracts International66-10B.
Subject:	Chemistry, Nuclear. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3194009
ISBN:	9780542374395

Technetium and rhenium radiopharmaceutical agents in nuclear medicine: Design and synthesis.
Lazarova, Neva.

Technetium and rhenium radiopharmaceutical agents in nuclear medicine: Design and synthesis. - 220 p.

Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5402.

Thesis (Ph.D.)--Syracuse University, 2005.

This study focuses on the design, development, and synthesis of technetium and rhenium radiopharmaceutical agents for imaging and therapy in nuclear medicine. Due to the inherent chemical similarities between technetium and rhenium, the non-radioactive rhenium was used as a surrogate for the technetium metal, which exists only as radioactive isotopes.

ISBN: 9780542374395Subjects--Topical Terms:

1916260
Chemistry, Nuclear.

Technetium and rhenium radiopharmaceutical agents in nuclear medicine: Design and synthesis.
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100 1 $a Lazarova, Neva. $3 1916259
245 1 0 $a Technetium and rhenium radiopharmaceutical agents in nuclear medicine: Design and synthesis.
300 $a 220 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5402.
500 $a Adviser: Jon A. Zubieta.
502 $a Thesis (Ph.D.)--Syracuse University, 2005.
520 $a This study focuses on the design, development, and synthesis of technetium and rhenium radiopharmaceutical agents for imaging and therapy in nuclear medicine. Due to the inherent chemical similarities between technetium and rhenium, the non-radioactive rhenium was used as a surrogate for the technetium metal, which exists only as radioactive isotopes.
520 $a Studies of the interaction of the metal ions Tc(I, III, V) and Re(I, III, V) with aromatic and aliphatic amines, carboxyl groups, thiols, and thioethers constitutes a significant segment of this work. After a careful investigation of the coordination preferences of the metal cores towards the different donor ligand systems, a series of single amino acid chelates (SAAC) and their complexes were designed and synthesized.
520 $a The conjugate (pendant) approach was implemented in the design of the radiopharmaceuticals. The three major components of this strategy, the biologically active molecule (BAM), the bifunctional chelator (BFCA), and the radiometal core, were explored. Chapters 2 and 3 focus on the single amino acid chelates, as the BFCA, for conjugation to a small peptide, acting as the BAM. Chapter 4 discusses the importance of thiols and thioethers in the development of technetium and rhenium metal complexes with charges ranging from +1 to -1. Chapter 5 demonstrates the utility of a series of cationic and ether-based agents as myocardial perfusion agents. Chapter 6 concentrates on the synthesis of brain imaging agents for the DAT, 5-HTT, and NET. Chapter 7 presents the improved and very convenient synthesis and thorough characterization of the [Re(H 2O)3(CO)3]Br starting material.
590 $a School code: 0659.
650 4 $a Chemistry, Nuclear. $3 1916260
650 4 $a Chemistry, Inorganic. $3 517253
650 4 $a Chemistry, Radiation. $3 1017804
650 4 $a Engineering, Biomedical. $3 1017684
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710 2 0 $a Syracuse University. $3 1017440
773 0 $t Dissertation Abstracts International $g 66-10B.
790 1 0 $a Zubieta, Jon A., $e advisor
790 $a 0659
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3194009