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Structure and properties of electros...

Casper, Cheryl L.

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Structure and properties of electrospun polymer fibers and applications in biomedical engineering.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Structure and properties of electrospun polymer fibers and applications in biomedical engineering./
作者:	Casper, Cheryl L.
面頁冊數:	165 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6853.
Contained By:	Dissertation Abstracts International66-12B.
標題:	Engineering, Materials Science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3200539
ISBN:	9780542458040

Structure and properties of electrospun polymer fibers and applications in biomedical engineering.
Casper, Cheryl L.

Structure and properties of electrospun polymer fibers and applications in biomedical engineering. - 165 p.

Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6853.

Thesis (Ph.D.)--University of Delaware, 2006.

Increased interest in nanotechnology has revived a fiber processing technique invented back in the 1930's. Electrospinning produces nanometer to micron size fibers that are not otherwise achievable using conventional fiber spinning methods. Due to small fiber diameters, high surface area, tailorable surface morphology, and the creation of an interconnected fibrous network, electrospun fibers have found use in a variety of applications. However, a multitude of parameters directly affect the electrospinning process thus requiring a fundamental understanding of how various parameters affect the process and resulting fiber properties. Accordingly, the focus of this dissertation is to provide insight on how solution characteristics and processing parameters directly affect the electrospinning process, and then apply this knowledge to create electrospun membranes for biomedical applications.

ISBN: 9780542458040Subjects--Topical Terms:

1017759
Engineering, Materials Science.

Structure and properties of electrospun polymer fibers and applications in biomedical engineering.
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245 1 0 $a Structure and properties of electrospun polymer fibers and applications in biomedical engineering.
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500 $a Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6853.
500 $a Adviser: John F. Rabolt.
502 $a Thesis (Ph.D.)--University of Delaware, 2006.
520 $a Increased interest in nanotechnology has revived a fiber processing technique invented back in the 1930's. Electrospinning produces nanometer to micron size fibers that are not otherwise achievable using conventional fiber spinning methods. Due to small fiber diameters, high surface area, tailorable surface morphology, and the creation of an interconnected fibrous network, electrospun fibers have found use in a variety of applications. However, a multitude of parameters directly affect the electrospinning process thus requiring a fundamental understanding of how various parameters affect the process and resulting fiber properties. Accordingly, the focus of this dissertation is to provide insight on how solution characteristics and processing parameters directly affect the electrospinning process, and then apply this knowledge to create electrospun membranes for biomedical applications.
520 $a These fundamental studies provided insight on how to control the electrospinning process; this knowledge was then utilized to electrospin fibrous membranes for biomedical applications. One aspect of this work focused on incorporating low molecular weight heparin (LMWH) into electrospun fibers. Heparin is known for its ability to bind growth factors and thus it plays an integral role in drug delivery and tissue engineering applications. The goal of this work was to fabricate functionalized electrospun fibers to produce a biologically active matrix that would allow for the binding and delivery of growth factors for possible drug delivery applications.
520 $a The electrospinning process was also utilized to fabricate native polymers such as collagen and gelatin into fiber form. The collagen and gelatin fibers were 2--6 mum in diameter and required crosslinking to stabilize the fibers. Crosslinking and sterilization protocols were investigated to optimize the conditions needed to produce collagen and gelatin electrospun membranes to be used in bone regeneration applications. (Abstract shortened by UMI.)
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650 4 $a Chemistry, Polymer. $3 1018428
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