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Effect of anthocyanin-rich extracts ...

Su, Ye.

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Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy./
作者:	Su, Ye.
面頁冊數:	101 p.
附註:	Source: Masters Abstracts International, Volume: 44-04, page: 1718.
Contained By:	Masters Abstracts International44-04.
標題:	Agriculture, Food Science and Technology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1431592
ISBN:	9780542476976

Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy.
Su, Ye.

Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy. - 101 p.

Source: Masters Abstracts International, Volume: 44-04, page: 1718.

Thesis (M.S.)--University of Maryland, College Park, 2006.

Anthocyanins are natural colorants, with potential chemopreventive activity. 5-Flurouracil (5-Fu) is a widely used cancer chemotherapeutic drug. However, it has serious side effects. Objective. To determine whether anthocyanin-rich-extracts (ARE) can increase the effectiveness of 5-Fu. Methods. Colon cancer cells were treated with ARE in combination with 5-Fu to assess in vitro whether ARE would enhance 5-Fu cytotoxicity. In vivo, rats were given diets with or without ARE for 14 days. On day 11, rats were injected with either 5-Fu or its vehicle. Total blood cells counts and pathological analyses were conducted. Results. ARE enhanced the growth inhibition by 5-Fu in colon cancer cell lines, but almost had no effect on normal colon cells. 5-Fu had serious side effects on the rats. Dietary ARE partially reduced the gastrointestinal damage by 5-Fu. Further studies with advanced tumor models are needed to assess effect of ARE on 5-Fu tumor inhibition in vivo .

ISBN: 9780542476976Subjects--Topical Terms:

1017813
Agriculture, Food Science and Technology.

Effect of anthocyanin-rich extracts on 5-flurouracil chemotherapy.
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