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Effects of aerobic vs resistive exer...

Gaillard, Trudy.

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Effects of aerobic vs resistive exercise on glucose transporter proteins and insulin sensitivity in obese nondiabetic female first degree relatives of African American patients with type 2 diabetes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of aerobic vs resistive exercise on glucose transporter proteins and insulin sensitivity in obese nondiabetic female first degree relatives of African American patients with type 2 diabetes./
Author:	Gaillard, Trudy.
Description:	190 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0229.
Contained By:	Dissertation Abstracts International66-01B.
Subject:	Health Sciences, Public Health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3161121
ISBN:	9780496944187

Effects of aerobic vs resistive exercise on glucose transporter proteins and insulin sensitivity in obese nondiabetic female first degree relatives of African American patients with type 2 diabetes.
Gaillard, Trudy.

Effects of aerobic vs resistive exercise on glucose transporter proteins and insulin sensitivity in obese nondiabetic female first degree relatives of African American patients with type 2 diabetes. - 190 p.

Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0229.

Thesis (Ph.D.)--The Ohio State University, 2005.

Background. Chronic physical activity has been shown to increase insulin sensitivity (IS) and lower rates of type 2 diabetes (T2DM). There have been no studies that examined the effects of aerobic (AT) and resistive (RT) training in obese, sedentary African Americans (AA) females, who are genetically predisposed to develop T2DM. Thus, the objectives of the present study were; (1) determine the effects of AT vs. RT on glucose transporter proteins (GLUT4) and insulin sensitivity; and (2) examine the impact of genetic inheritance (family history {FH}) on these indices.

ISBN: 9780496944187Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

Effects of aerobic vs resistive exercise on glucose transporter proteins and insulin sensitivity in obese nondiabetic female first degree relatives of African American patients with type 2 diabetes.
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035 $a (UnM)AAI3161121
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100 1 $a Gaillard, Trudy. $3 1915031
245 1 0 $a Effects of aerobic vs resistive exercise on glucose transporter proteins and insulin sensitivity in obese nondiabetic female first degree relatives of African American patients with type 2 diabetes.
300 $a 190 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0229.
500 $a Advisers: William M. Sherman; Kwame Osei.
502 $a Thesis (Ph.D.)--The Ohio State University, 2005.
520 $a Background. Chronic physical activity has been shown to increase insulin sensitivity (IS) and lower rates of type 2 diabetes (T2DM). There have been no studies that examined the effects of aerobic (AT) and resistive (RT) training in obese, sedentary African Americans (AA) females, who are genetically predisposed to develop T2DM. Thus, the objectives of the present study were; (1) determine the effects of AT vs. RT on glucose transporter proteins (GLUT4) and insulin sensitivity; and (2) examine the impact of genetic inheritance (family history {FH}) on these indices.
520 $a Methodology. Twenty (20) AA with FH were randomly assigned to 12weeks (12wks) of AT[(70% of VO2max) (n = 10)] or RT[(70% of 1 (RM) (n = 10)]. Ten(10) AA females without FH served as reference controls [(CN) (n = 10)]. OGTT (glucose, insulin, c-peptide), systolic and diastolic blood pressure (SBP, DBP) were obtained in each subject. IS was measured by the Homeostasis Model Assessment (HOMA-IR). Body composition was assessed via BOD POD. Each subject completed a VO2max test and 1 repetition maximal (1RM) for chest press (CP) and leg press (LP). Skeletal muscle biopsy for GLUT4 was randomly obtained in a sub-set of each group. Baseline measurements were repeated in subjects with FH after 12wks.
520 $a Results. The fasting plasma glucose, insulin and c-peptide, HOMA-IR, SBP, DBP, %body fat, were statistically higher in subjects with FH vs. CN. The mean VO2max and %lean body mass was statistically lower in our subjects with FH vs. CN. Twelve weeks of AT significantly reduced the SBP and DBP, whereas, RT significant increased body strength. HOMA-IR was not changed by AT or RT. The GLUT4 was not different among our groups. RT was associated with a 24.8% increase in GLUT4 whereas, AT decreased GLUT4 by 10.8% from baseline, but these values were not statistically significant.
520 $a Summary. Obese AA females with FH of T2DM have greater %body fat, insulin resistance, significantly higher BP and lower V02max when compared to healthy aged-matched AA controls without FH. The two exercise modalities had significant but varying effects on hemodynamic parameters. AT vs. RT had no effects on metabolic or anthropometric parameters measured in our previously sedentary obese AA females.
590 $a School code: 0168.
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Health Sciences, Recreation. $3 1018003
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Black Studies. $3 1017673
690 $a 0573
690 $a 0575
690 $a 0487
690 $a 0325
710 2 0 $a The Ohio State University. $3 718944
773 0 $t Dissertation Abstracts International $g 66-01B.
790 1 0 $a Sherman, William M., $e advisor
790 1 0 $a Osei, Kwame, $e advisor
790 $a 0168
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3161121