東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

An in vitro model system for evaluat...

Rubin, Michael.

Linked to FindBook

Google Book

Amazon

博客來

An in vitro model system for evaluating substantive antimicrobial agents in simulated dental plaque biofilms.

Record Type:	Electronic resources : Monograph/item
Title/Author:	An in vitro model system for evaluating substantive antimicrobial agents in simulated dental plaque biofilms./
Author:	Rubin, Michael.
Description:	121 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2414.
Contained By:	Dissertation Abstracts International66-05B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176220
ISBN:	9780542157349

An in vitro model system for evaluating substantive antimicrobial agents in simulated dental plaque biofilms.
Rubin, Michael.

An in vitro model system for evaluating substantive antimicrobial agents in simulated dental plaque biofilms. - 121 p.

Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2414.

Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick and University of Medicine and Dentistry of New Jersey, 2005.

Dental plaque is a multi-species biofilm that, left untreated, can produce diseases including caries, gingivitis, and periodontitis. A model system for simulating dental plaque biofilms was developed and used for evaluating antiplaque agents and formulations.

ISBN: 9780542157349Subjects--Topical Terms:

1017734
Biology, Microbiology.

An in vitro model system for evaluating substantive antimicrobial agents in simulated dental plaque biofilms.
LDR:03149nmm 2200313 4500 001 1825173
005 20061206115436.5
008 130610s2005 eng d
020 $a 9780542157349
035 $a (UnM)AAI3176220
035 $a AAI3176220
040 $a UnM $c UnM
100 1 $a Rubin, Michael. $3 1914196
245 1 3 $a An in vitro model system for evaluating substantive antimicrobial agents in simulated dental plaque biofilms.
300 $a 121 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2414.
500 $a Director: Stanley Katz.
502 $a Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick and University of Medicine and Dentistry of New Jersey, 2005.
520 $a Dental plaque is a multi-species biofilm that, left untreated, can produce diseases including caries, gingivitis, and periodontitis. A model system for simulating dental plaque biofilms was developed and used for evaluating antiplaque agents and formulations.
520 $a A simulated dental biofilm was attempted by constructing a multi-species inoculum of common oral microorganisms that included streptococci, fusobacteria, and actinomycetes. The biofilm was grown in Phytone Peptone Yeast Extract medium (PPY) which were supplemented with various concentrations of sucrose and/or saliva. Because of streptococcal competition, the biofilms that were produced using this model became mono-species instead of multi-species.
520 $a This monospecies model was used to evaluate commercially available antiplaque mouth rinses that contained chlorhexidine or botanical essential oils. A combination of spectrophotometry and the use of selective general growth media were used to evaluate the viability, growth and survival of the biofilms.{09}A 30-second exposure to the essential oil-containing mouth rinse reduced the population of a 48-hour biofilm by approximately 75%. The population of the biofilm treated with the essential oil containing formulation subsequently doubled within 24 hours to the same level of viable organisms found in the untreated biofilm. By comparison, the population of a 48-hour biofilm treated with 0.12% chlorhexidine showed the same level of viable organisms as the untreated biofilm; however, the population and biomass of the chlorhexidine treated biofilm did not increase or decrease for an additional 72 hours. This indicated that in this model chlorhexidine was bacteriostatic and not bactericidal. The extended duration of the antimicrobial activity of chlorhexidine, in situ, indicated that chlorhexidine was substantive.
520 $a Therefore, this model, although single species, provided an easily accessible means for evaluating antimicrobial compounds and formulations against dental plaque and can also simultaneously distinguish between substantive agents and non-substantive agents.
590 $a School code: 0801.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Health Sciences, Dentistry. $3 1019378
690 $a 0410
690 $a 0567
710 2 0 $a Rutgers The State University of New Jersey - New Brunswick and University of Medicine and Dentistry of New Jersey. $3 1023857
773 0 $t Dissertation Abstracts International $g 66-05B.
790 1 0 $a Katz, Stanley, $e advisor
790 $a 0801
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176220