東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Nanomaterial-based electronic detection.

Polsky, Ronen.

FindBook

Google Book

Amazon

博客來

Nanomaterial-based electronic detection.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Nanomaterial-based electronic detection./
作者:	Polsky, Ronen.
面頁冊數:	181 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6355.
Contained By:	Dissertation Abstracts International65-12B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3155987
ISBN:	9780496167036

Nanomaterial-based electronic detection.
Polsky, Ronen.

Nanomaterial-based electronic detection. - 181 p.

Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6355.

Thesis (Ph.D.)--New Mexico State University, 2004.

Nanomaterials have been the subjects of intense current research recently due to their unique structural, electrical, and mechanical properties. The ratio of surface atoms to internal atoms is greatly responsible for many of the properties associated with nanomaterials and makes the precise control over the shape and architecture of the material of the utmost importance. It is the purpose of this thesis to take advantage of such research by applying novel nanomaterials, i.e. metal nanoparticles and carbon nanotubes, towards new methods and protocols for electronic detection.

ISBN: 9780496167036Subjects--Topical Terms:

586156
Chemistry, Analytical.

Nanomaterial-based electronic detection.
LDR:03772nmm 2200289 4500 001 1824308
005 20061130141902.5
008 130610s2004 eng d
020 $a 9780496167036
035 $a (UnM)AAI3155987
035 $a AAI3155987
040 $a UnM $c UnM
100 1 $a Polsky, Ronen. $3 1913390
245 1 0 $a Nanomaterial-based electronic detection.
300 $a 181 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6355.
500 $a Chair: Joseph Wang.
502 $a Thesis (Ph.D.)--New Mexico State University, 2004.
520 $a Nanomaterials have been the subjects of intense current research recently due to their unique structural, electrical, and mechanical properties. The ratio of surface atoms to internal atoms is greatly responsible for many of the properties associated with nanomaterials and makes the precise control over the shape and architecture of the material of the utmost importance. It is the purpose of this thesis to take advantage of such research by applying novel nanomaterials, i.e. metal nanoparticles and carbon nanotubes, towards new methods and protocols for electronic detection.
520 $a Magnetic beads are proposed as a platform for DNA hybridization reactions demonstrated as proof of concept using an electrochemical enzymatic reaction. It represents the first example of coupling a magnetic isolation with electrochemical detection of DNA hybridization. The magnetic bead-based approach is further extended to colloidal gold nanoparticle labels. Signal amplification is achieved through the catalytic precipitation of silver onto the gold nanoparticles. TEM imaging indicates that the hybridization event results in a three-dimensional aggregate structure in which duplex segments link the metal nanoparticles and magnetic spheres, and that most of this assembly is covered with the silver precipitate. A magnet placed under the working electrode is used to "anchor" this silver-coated aggregated structure leading to a direct contact of the metal tag with the surface (in connection to the magnetic collection) and enables the solid-state electrochemical transduction (without prior dissolution and subsequent electrodeposition of the metal), using oxidative dissolution of the silver tracer. A cadmium sulfide nanoparticle label is also used. The new protocol combines the amplification features of nanoparticle/polynucleotides assemblies and highly sensitive stripping potentiometric detection of cadmium, with an effective magnetic isolation of the duplex.
520 $a "Electroactive beads" are described involving the use of polystyrene microbead tags which are internally 'loaded' with water-insoluble electroactive markers. Approximately 5 x 1011 molecules of the ferrocenecarboxaldehyde (FCA) marker have thus been entrapped in a single microsphere. The resulting "electroactive beads" are capable of carrying a huge number of marker molecules and hence offer a dramatic amplification of single hybridization events and remarkably low detection limits (down to 5.1 x 10-21mol or &sim;31,000 molecules). The huge signal amplification is coupled to an effective discrimination against non-complementary nucleic acids. Two different electroactive labels, ferrocenecarboxaldehyde and ferrocene, allowed dual target detection capability coupled with high sensitivity and effective discrimination against non-complementary nucleic acids. Immunological detection of protein IgG is also described. (Abstract shortened by UMI.)
590 $a School code: 0143.
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0486
710 2 0 $a New Mexico State University. $3 783784
773 0 $t Dissertation Abstracts International $g 65-12B.
790 1 0 $a Wang, Joseph, $e advisor
790 $a 0143
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3155987