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The effect of angiotensin II recepto...

Pourdjabbar, Ali.

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The effect of angiotensin II receptor blockade, prior to, during and after a myocardial infarction in rats with and without insulin resistance.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effect of angiotensin II receptor blockade, prior to, during and after a myocardial infarction in rats with and without insulin resistance./
Author:	Pourdjabbar, Ali.
Description:	169 p.
Notes:	Source: Masters Abstracts International, Volume: 44-01, page: 0230.
Contained By:	Masters Abstracts International44-01.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR02533
ISBN:	9780494025338

The effect of angiotensin II receptor blockade, prior to, during and after a myocardial infarction in rats with and without insulin resistance.
Pourdjabbar, Ali.

The effect of angiotensin II receptor blockade, prior to, during and after a myocardial infarction in rats with and without insulin resistance. - 169 p.

Source: Masters Abstracts International, Volume: 44-01, page: 0230.

Thesis (M.Sc.)--University of Toronto (Canada), 2005.

Since diabetes and myocardial infarction (MI) are associated with an up-regulation of the renin-angiotensin system (RAS), we hypothesized that Angiotensin-II receptor blockers will be beneficial in the peri- and post-large-MI periods, in Wistar and insulin-resistant rats (ZFR).

ISBN: 9780494025338Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The effect of angiotensin II receptor blockade, prior to, during and after a myocardial infarction in rats with and without insulin resistance.
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020 $a 9780494025338
035 $a (UnM)AAIMR02533
035 $a AAIMR02533
040 $a UnM $c UnM
100 1 $a Pourdjabbar, Ali. $3 1913246
245 1 4 $a The effect of angiotensin II receptor blockade, prior to, during and after a myocardial infarction in rats with and without insulin resistance.
300 $a 169 p.
500 $a Source: Masters Abstracts International, Volume: 44-01, page: 0230.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2005.
520 $a Since diabetes and myocardial infarction (MI) are associated with an up-regulation of the renin-angiotensin system (RAS), we hypothesized that Angiotensin-II receptor blockers will be beneficial in the peri- and post-large-MI periods, in Wistar and insulin-resistant rats (ZFR).
520 $a In Wistar rats, Losartan at a high-dose (30mg/kg/day) caused significant hypotension resulting in increased 24hour mortality. In the 24hour post-MI survivors, Losartan administered progressively (3mg/kg/day progressively increased to 30mg/kg/day), reduced mortality between day-1 and day-38, improved ventricular remodeling, hemodynamics and fetal-gene expression profiles. In ZFR, Losartan administered progressively reduced early ventricular arrhythmias resulting in improved survival. Chronically, Losartan reduced cardiac hypertrophy and fetal-gene re-expression, however it did not improve ventricular remodeling and hemodynamics.
520 $a These results indicate that the peri- and post-MI blockade of the RAS reduces arrhythmias and improves peri-MI survival only in the ZFR, while the chronic treatment improved the 24hour-38day survival, ventricular function and remodeling, fetal-gene and GLUT-4 mRNA expression in normal animals.
590 $a School code: 0779.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0433
690 $a 0487
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Masters Abstracts International $g 44-01.
790 $a 0779
791 $a M.Sc.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR02533