東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Factors affecting the regulation of ...

Flory, Graham S.

Linked to FindBook

Google Book

Amazon

博客來

Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey./
Author:	Flory, Graham S.
Description:	126 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1212.
Contained By:	Dissertation Abstracts International66-02B.
Subject:	Psychology, Psychobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3163796
ISBN:	9780496981151

Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey.
Flory, Graham S.

Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey. - 126 p.

Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1212.

Thesis (Ph.D.)--University of Michigan, 2005.

It has been suggested that the motivation (of both humans and animals) to self-administer drugs is governed by a homeostatic mechanism that acts to achieve and maintain a constant level of circulating drug in the brain. This notion is both central to a prominent contemporary theory of drug addiction (the "reward-allostasis" model) and has for decades been the source of considerable confusion in the ethanol self-administration literature, as animals invariably self-administer between 300--400% more ethanol by the intravenous route than they do by the oral route.

ISBN: 9780496981151Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey.
LDR:02725nmm 2200301 4500 001 1824031
005 20061128082918.5
008 130610s2005 eng d
020 $a 9780496981151
035 $a (UnM)AAI3163796
035 $a AAI3163796
040 $a UnM $c UnM
100 1 $a Flory, Graham S. $3 1913124
245 1 0 $a Factors affecting the regulation of intravenous drug self-administration by the rhesus monkey.
300 $a 126 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1212.
500 $a Chairman: James H. Woods.
502 $a Thesis (Ph.D.)--University of Michigan, 2005.
520 $a It has been suggested that the motivation (of both humans and animals) to self-administer drugs is governed by a homeostatic mechanism that acts to achieve and maintain a constant level of circulating drug in the brain. This notion is both central to a prominent contemporary theory of drug addiction (the "reward-allostasis" model) and has for decades been the source of considerable confusion in the ethanol self-administration literature, as animals invariably self-administer between 300--400% more ethanol by the intravenous route than they do by the oral route.
520 $a Data obtained in this thesis demonstrate the existence of a stable ascending limb to the dose-response curve for intravenously self-administered ethanol, cocaine, and dilaudid on a continuous schedule of reinforcement in which increases in response rate result in an increased rate of drug intake. These data make it clear that the attainment and maintenance of a threshold level of drug in the brain is not a necessary component of an animal's motivation to self-administer it. Instead, at the relatively low doses that comprise the ascending limb of this function (which include those used in the oral ethanol self-administration paradigm), an increase in dose is accompanied by an increase in the rate of intake.
520 $a This phenomenon may be due to the fact that with larger doses, a given drug effect can be achieved more rapidly than with smaller doses, and that, at low drug doses, faster rates of drug accumulation may impart a greater degree of reinforcing efficacy. Support for this possibility comes from a finding of this thesis that, with dose held constant, an increase in the rate of intravenous infusion engendered significantly more rapid rates of responding and consequently, more rapid rates of drug intake.
590 $a School code: 0127.
650 4 $a Psychology, Psychobiology. $3 1017821
650 4 $a Psychology, Experimental. $3 517106
690 $a 0349
690 $a 0623
710 2 0 $a University of Michigan. $3 777416
773 0 $t Dissertation Abstracts International $g 66-02B.
790 1 0 $a Woods, James H., $e advisor
790 $a 0127
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3163796