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Studies of polycyclic aromatic hydro...

Eickhoff, Curtis Van.

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Studies of polycyclic aromatic hydrocarbons in dungeness crabs: Biomonitoring, physiologically based toxicokinetic model, and human health risk assessment.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Studies of polycyclic aromatic hydrocarbons in dungeness crabs: Biomonitoring, physiologically based toxicokinetic model, and human health risk assessment./
Author:	Eickhoff, Curtis Van.
Description:	311 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3030.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Environmental Sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR03110
ISBN:	9780494031100

Studies of polycyclic aromatic hydrocarbons in dungeness crabs: Biomonitoring, physiologically based toxicokinetic model, and human health risk assessment.
Eickhoff, Curtis Van.

Studies of polycyclic aromatic hydrocarbons in dungeness crabs: Biomonitoring, physiologically based toxicokinetic model, and human health risk assessment. - 311 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3030.

Thesis (Ph.D.)--Simon Fraser University (Canada), 2005.

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous pollutants released into the environment from the incomplete combustion of organic material and petrochemical sources. PAH are persistent molecules that partition into sediments and biota in the aquatic environment. PAH such as benzo[a]pyrene, are of concern because they are metabolised into potentially carcinogenic chemicals that can cause tumours in fish and mammals.

ISBN: 9780494031100Subjects--Topical Terms:

676987
Environmental Sciences.

Studies of polycyclic aromatic hydrocarbons in dungeness crabs: Biomonitoring, physiologically based toxicokinetic model, and human health risk assessment.
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035 $a (UnM)AAINR03110
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100 1 $a Eickhoff, Curtis Van. $3 1913046
245 1 0 $a Studies of polycyclic aromatic hydrocarbons in dungeness crabs: Biomonitoring, physiologically based toxicokinetic model, and human health risk assessment.
300 $a 311 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3030.
502 $a Thesis (Ph.D.)--Simon Fraser University (Canada), 2005.
520 $a Polycyclic aromatic hydrocarbons (PAH) are ubiquitous pollutants released into the environment from the incomplete combustion of organic material and petrochemical sources. PAH are persistent molecules that partition into sediments and biota in the aquatic environment. PAH such as benzo[a]pyrene, are of concern because they are metabolised into potentially carcinogenic chemicals that can cause tumours in fish and mammals.
520 $a The purpose of this research was three-fold, (1) to explore the use of the dungeness crab for monitoring PAH in the aquatic environment, (2) to adapt a physiologically based toxicokinetic (PBTK) model to describe the disposition of benzo[a]pyrene in the dungeness crab, and (3) to examine the lifetime cancer risk to humans associated with the consumption of PAH contaminated crabs.
520 $a Kitimat Arm is an aquatic ecosystem in British Columbia, contaminated with PAH by industrial processes. Dungeness crabs were collected at several sites within this fjord, and concentrations of PAH were determined in the crabs by GC/MS. A synchronous fluorescence spectroscopy assay was adapted to screen crab haemolymph samples for pyrene and its metabolites. PAH could be readily determined in the tissues of crabs and tissue concentrations decreased with distance from the source of the PAH contamination. Therefore, crabs were an effective tool for monitoring PAH contamination in the fjord.
520 $a A PBTK model was adapted to describe the disposition of benzo[a]pyrene in the dungeness crab. The model was composed of seven compartments representing the major tissues of the crab. The flux of benzo[a]pyrene in each compartment was described by algebraic and mass-balance differential equations, coded into Visual Basic and solved numerically by an Excel spreadsheet. The model was implemented with parameters, calibrated, and validated using data obtained empirically. The model successfully predicted benzo[a]pyrene concentrations in the tissue compartments after simulated exposures to benzo[a]pyrene by intravascular, oral and water exposure routes.
520 $a A human health risk assessment was conducted to evaluate the lifetime cancer risk associated with consumption of PAH contaminated crabs from Kitimat Arm. Deterministic and stochastic risk assessment models were implemented. There was an excess cancer risk associated with consumption of crabs from Hospital Beach, an area near the source of PAH contamination.
590 $a School code: 0791.
650 4 $a Environmental Sciences. $3 676987
650 4 $a Health Sciences, Toxicology. $3 1017752
690 $a 0768
690 $a 0383
710 2 0 $a Simon Fraser University (Canada). $3 1020621
773 0 $t Dissertation Abstracts International $g 66-06B.
790 $a 0791
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR03110