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Functional MRI studies of working me...

Schon, Karin.

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Functional MRI studies of working memory maintenance and long-term encoding.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Functional MRI studies of working memory maintenance and long-term encoding./
Author:	Schon, Karin.
Description:	232 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1749.
Contained By:	Dissertation Abstracts International66-03B.
Subject:	Psychology, Cognitive. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3167747
ISBN:	9780542032974

Functional MRI studies of working memory maintenance and long-term encoding.
Schon, Karin.

Functional MRI studies of working memory maintenance and long-term encoding. - 232 p.

Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1749.

Thesis (Ph.D.)--Boston University, 2005.

The main focus of this thesis was to further our understanding of interactions between working memory (WM) and long-term memory (LTM). In a series of three experiments this thesis investigated the role of medial temporal lobes (MTL) and prefrontal cortex (PFC) in the active maintenance of visual-nonspatial and visual-spatial information and its relationship to long-term encoding using functional magnetic resonance imaging and delayed match-to-sample (DMS) tasks in healthy young human adults.

ISBN: 9780542032974Subjects--Topical Terms:

1017810
Psychology, Cognitive.

Functional MRI studies of working memory maintenance and long-term encoding.
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035 $a (UnM)AAI3167747
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100 1 $a Schon, Karin. $3 1912771
245 1 0 $a Functional MRI studies of working memory maintenance and long-term encoding.
300 $a 232 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1749.
500 $a Major Professor: Chantal E. Stern.
502 $a Thesis (Ph.D.)--Boston University, 2005.
520 $a The main focus of this thesis was to further our understanding of interactions between working memory (WM) and long-term memory (LTM). In a series of three experiments this thesis investigated the role of medial temporal lobes (MTL) and prefrontal cortex (PFC) in the active maintenance of visual-nonspatial and visual-spatial information and its relationship to long-term encoding using functional magnetic resonance imaging and delayed match-to-sample (DMS) tasks in healthy young human adults.
520 $a Experiment #1 elucidates the role of previous stimulus experience (novel vs. familiar objects) and of stimulus domain (spatial locations vs. visual objects) in delay-period activity. The results of this experiment indicate that actively maintaining novel objects during brief memory delays recruits MTL areas. Activity in the PFC is greater during maintenance of familiar compared to novel objects, and maintenance of spatial and nonspatial information recruits different subregions within the PFC. These results support the hypothesis that MTL regions are critical for the active maintenance of stimuli that have no previous representation in the brain. In addition, the findings support the idea that the PFC is recruited when familiar stimuli need to be monitored (i.e., when interference is high among them).
520 $a Experiment #2 combines a DMS task with a post-scan subsequent recognition memory assessment to test the hypothesis that during WM maintenance, novel sample stimuli are encoded into long-term memory. The results showed that delay activity in the MTL is correlated with subsequent memory, and support the idea that sustained activity in the MTL is required for long-term encoding.
520 $a Experiment #3 tests the hypothesis that encoding-related activity during the delay-period (experiment #2) is modulated by the neurotransmitter acetylcholine. The results of this experiment demonstrate that fMRI activity within the MTL is attenuated in individuals who received an injection of the cholinergic antagonist scopolamine.
520 $a In conclusion, these three experiments provide strong support for a role of the MTL in WM maintenance of novel information for which no previous representation exists in the brain, and for a role in long-term encoding during WM. In contrast, the PFC is critical for the maintenance of familiar stimuli, for which LTM representations already exist.
590 $a School code: 0017.
650 4 $a Psychology, Cognitive. $3 1017810
650 4 $a Psychology, Experimental. $3 517106
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0633
690 $a 0623
690 $a 0317
710 2 0 $a Boston University. $3 1017454
773 0 $t Dissertation Abstracts International $g 66-03B.
790 1 0 $a Stern, Chantal E., $e advisor
790 $a 0017
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3167747